Dr. Charles Eberhart, MD

• Neuropathology

• Anatomic Pathology

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• Johns Hopkins University School Med

  Residency Hospital

• University Of Texas Southwestern Medical Center

  Medical School, 1997

• Strategies to Enhance the Distribution of Nanotherapeutics in the Brain, 2017-07-21

• HIF-1a- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy, 2017-11-02

• TORC1/2 kinase inhibition depletes glutathione and synergizes with carboplatin to suppress the growth of MYC-driven medulloblastoma, 2021-02-08

• Isolated endogenousNocardiaendophthalmitis after immunosuppression, 2012-01-26

• RNA interference-mediated c-MYC inhibition prevents cell growth and decreases sensitivity to radio- and chemotherapy in childhood medulloblastoma cells, 2009-01-10

• Therapeutic Vulnerability to ATR Inhibition in ConcurrentNF1andATRX-Deficient/ALT-Positive High-Grade Solid Tumors, 2022-06-19

• Temperature and species-dependent regulation of browning in retrobulbar fat, 2021-02-04

• NGS Analysis Confirms CommonTP53andRB1Mutations, and SuggestsMYCAmplification in Ocular Adnexal Sebaceous Carcinomas, 2021-08-06

• Lateral inhibition of Notch signaling in neoplastic cells, 2014-12-09

• Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma, 2016-01-09

• Molecular Pathways: Not a Simple Tube-The Many Functions of Blood Vessels, 2014-07-29

• Molecular and Morphologic Correlates of the Alternative Lengthening of Telomeres Phenotype in High Grade Astrocytomas, 2012-09-24

• NKX3.1 as a Marker of Prostatic Origin in Metastatic Tumors, 2011-03-25

• ACVR1C/SMAD2 signaling promotes invasion and growth in retinoblastoma, 2018-11-06

• Methylome Alterations "Mark” New Therapeutic Opportunities in Glioblastoma, 2012-10-16

• Invasive Squamous Cell Carcinomas and Precursor Lesions on UV-Exposed Epithelia Demonstrate Concordant Genomic Complexity in Driver Genes, 2020-05-27

• BRAF Activation Induces Transformation and Then Senescence in Human Neural Stem Cells: A Pilocytic Astrocytoma Model, 2011-06-01

• Three Down and One To Go: Modeling Medulloblastoma Subgroups, 2012-02-14

• Melanoma subtypes demonstrate distinct PD-L1 expression profiles, 2017-07-24

• Sleeping Beautyinsertional mutagenesis reveals important genetic drivers of central nervous system embryonal tumors., 2019-01-23

• No Increase in IgG4-positive Plasma Cells in Limbal Rosai-Dorfman Disease, 2015-01-30

• Decreased 5-Hydroxymethylcytosine Is Associated with Neural Progenitor Phenotype in Normal Brain and Shorter Survival in Malignant Glioma, 2012-07-19

• Applications of chemical exchange saturation transfer MRI in identifying genetic markers in gliomas, 2022-04-05

• Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells, 2013-07-27

• Increased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virus, 2005-02-17

• Inhibition of enhancer of zest homologue 2 is a potential therapeutic target for high-MYC medulloblastoma, 2019-01-10

• Just Say No to ATOH: HowHIC1Methylation Might Predispose Medulloblastoma to Lineage Addiction, 2008-11-01

• A developmental defect in astrocytes inhibits programmed regression of the hyaloid vasculature in the mammalian eye, 2011-02-26

• Identifying Corneal Infections in Formalin-Fixed Specimens Using Next Generation Sequencing, 2018-01-01

• Identification of astrocytoma associated genes including cell surface markers, 2004-07-21

• Discriminating MGMT Promoter Methylation Status in Patients with Glioblastoma Employing Amide Proton Transfer-Weighted MRI Metrics, 2017-12-12

• OTME-9. Comprehensive Metabolic Profiling Of high MYC Medulloblastoma Reveals Key Differences Between InVitroAnd InVivoGlucose And Glutamine Usage, 2021-07-05

• Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma, 2012-11-25

• High-Risk Medulloblastoma: Doesc-mycAmplification Overrule Histopathology?, 2015-07-17

• MicroRNA (miR) 125b regulates cell growth and invasion in pediatric low grade glioma, 2018-08-21

• EphrinB2 controls vessel pruning through STAT1-JNK3 signaling, 2015-03-26

• Anti-proliferative activity of the quassinoid NBT-272 in childhood medulloblastoma cells, 2007-01-25

• Abnormal DNA Methylation of CD133 in Colorectal and Glioblastoma Tumors, 2008-10-01

• Notch Signaling Activation in Pediatric Low-Grade Astrocytoma, 2014-12-04

• Peripheral retinal arteriolar leakage in giant cell arteritis: a case report, 2021-01-29

• CNS-PNETs withC19MCamplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity, 2014-05-20

• Spatial enrichment of cellular states in glioblastoma, 2020-05-24

• Predicting IDH mutation status in grade-II gliomas using amide proton transfer-weighted (APTw) MRI, 2017-07-16

• Yes-Associated Protein 1 (YAP1) Is Widely Expressed in Human Brain Tumors and Promotes Glioblastoma Growth, 2011-06-10

• Pathological and Molecular Advances in Pediatric Low Grade Astrocytoma, 2012-10-29

• NOTCH Pathway Blockade Depletes CD133-Positive Glioblastoma Cells and Inhibits Growth of Tumor Neurospheres and Xenografts, 2010-05-21

• OTX2 Represses Myogenic and Neuronal Differentiation in Medulloblastoma Cells, 2012-09-17

• Detection of Human Papillomavirus in Squamous Lesions of the Conjunctiva Using RNA and DNA In-Situ Hybridization, 2022-06-29

• Incidence and clinicopathologic features of H3 K27M mutations in adults with radiographically-determined midline gliomas, 2019-03-12

• Frondoside A Inhibits a MYC-driven Medulloblastoma Model Derived from Human Induced Pluripotent Stem Cells, 2021-03-15

• BCOR Internal Tandem Duplication Expression in Neural Stem Cells Promotes Growth, Invasion, and Expression of PRC2 Targets, 2021-04-10

• Scleral Penetration of an Unusually Aggressive Case of a Retinal Hemangioblastoma, 2014-04-23

• Identifying Recurrent Malignant Glioma after Treatment Using Amide Proton Transfer-Weighted MR Imaging: A Validation Study with Image-Guided Stereotactic Biopsy, 2018-10-26

• RNA sequencing of corneas from two keratoconus patient groups identifies potential biomarkers and decreased NRF2-antioxidant responses, 2020-06-18

• The oncogenic circular RNAcirc_63706is a potential therapeutic target in sonic hedgehog-subtype childhood medulloblastomas, 2023-03-10

• Highly PEGylated DNA Nanoparticles Provide Uniform and Widespread Gene Transfer in the Brain, 2015-03-11

• Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells, 2015-10-13

• Notch Signaling in Prostate Cancer: A Moving Target, 2014-04-16

• LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumorigenesis through a pro-invasive genetic program, 2013-07-06

• Myc and loss of p53 cooperate to drive formation of choroid plexus carcinoma, 2019-03-18

• Notch3 Activation Promotes Invasive Glioma Formation in a Tissue Site-Specific Manner, 2011-01-18

• EGFR Activates a TAZ-driven Oncogenic Program in Glioblastoma, 2021-04-28

• Prolonged Inhibition of Glioblastoma Xenograft Initiation and Clonogenic Growth Following In Vivo Notch Blockade, 2013-04-29

• Controlled release of corticosteroid with biodegradable nanoparticles for treating experimental autoimmune uveitis, 2019-01-17

• Arsenic trioxide inhibits Hedgehog, Notch and stem cell properties in glioblastoma neurospheres, 2014-03-31

• Multi-layered core-sheath fiber membranes for controlled drug release in the local treatment of brain tumor, 2019-11-29

• RNA binding protein RBM14 promotes radio-resistance in glioblastoma by regulating DNA repair and cell differentiation, 2014-04-27

• Neoplastic cells are a rare component in human glioblastoma microvasculature, 2012-01-30

• Beta-Amyloid, Phospho-Tau and Alpha-Synuclein Deposits Similar to Those in the Brain Are Not Identified in the Eyes of Alzheimer's and Parkinson's Disease Patients, 2013-06-28

• Tissue Microarray Analysis of Cyclin-Dependent Kinase Inhibitors p21 and p16 in Fuchs Dystrophy, 2012-09-18

• Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct, 2011-06-17

• MYC drives Group 3 medulloblastoma through transformation of Sox2+astrocyte progenitor cells, 2019-03-12

• Increased 5-hydroxymethylcytosine and decreased 5-methylcytosine are indicators of global epigenetic dysregulation in diffuse intrinsic pontine glioma, 2014-06-03

• An immunocompetent mouse model of human glioblastoma, 2017-05-15

• Complement component 3 from astrocytes mediates retinal ganglion cell loss during neuroinflammation, 2021-09-06

• The Notch Target Hes1 Directly Modulates Gli1 Expression and Hedgehog Signaling: A Potential Mechanism of Therapeutic Resistance, 2010-12-15

• Non-adhesive and Highly-stable Biodegradable Nanoparticles that Provide Widespread and Safe Transgene Expression in Orthotopic Brain Tumors, 2021-04-18

• Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target, 2014-12-26

• Pharmacological WNT Inhibition Reduces Proliferation, Survival and Clonogenicity of Glioblastoma Cells, 2015-06-21

• Ocular MECP2 Protein Expression in Patients with and without Rett Syndrome, 2010-07-01

• The therapeutic and diagnostic potential of regulatory noncoding RNAs in medulloblastoma, 2019-09-06

• A neurodevelopmental epigenetic programme mediated by SMARCD3-DAB1-Reelin signalling is hijacked to promote medulloblastoma metastasis, 2023-02-27

• Immunohistochemical Characterization of Procaspase-3 Overexpression as a Druggable Target With PAC-1, a Procaspase-3 Activator, in Canine and Human Brain Cancers, 2019-02-25

• Molecular Diagnostics in Embryonal Brain Tumors, 2013-02-05

• Establishment and Biological Characterization of a Panel of Glioblastoma Multiforme (GBM) and GBM Variant Oncosphere Cell Lines, 2016-03-30

• Notch Signaling Promotes Growth and Invasion in Uveal Melanoma, 2012-01-06

• Sunitinib malate-loaded biodegradable microspheres for the prevention of corneal neovascularization in rats, 2020-08-18

• SnapShot: Medulloblastoma, 2014-12-08

• Effects ofZeng Sheng Ping/ACAPHA on Malignant Brain Tumor Growth and Notch Signaling, 2013-02-05

• Shear-thinning viscous materials for subconjunctival injection of microparticles, 2020-11-25

• Rabbit Model of Human Gliomas: Implications for Intra-Arterial Drug Delivery, 2017-01-19

• Ribavirin as a potential therapeutic for atypical teratoid/rhabdoid tumors, 2018-01-03

• 5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft, 2013-09-16

• Podocalyxin-Like Protein Is Expressed in Glioblastoma Multiforme Stem-Like Cells and Is Associated with Poor Outcome, 2013-10-16

• Hypoxia Promotes Uveal Melanoma Invasion through Enhanced Notch and MAPK Activation, 2014-08-28

• Mutant IDH1 promotes phagocytic function of microglia/macrophages in gliomas by downregulating ICAM1, 2021-06-05

• Even Cancers Want Commitment: Lineage Identity and Medulloblastoma Formation, 2008-08-12

• ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner, 2018-09-18

• Three-Dimensional Amide Proton Transfer MR Imaging of Gliomas: Initial Experience and Comparison with Gadolinium Enhancement, 2013-02-25

• ADAM3Acopy number gains occur in a subset of conjunctival squamous cell carcinoma and its high grade precursors, 2019-09-05

• Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer, 2009-03-03

• Interleukin-17 Retinotoxicity Is Prevented by Gene Transfer of a Soluble Interleukin-17 Receptor Acting as a Cytokine Blocker: Implications for Age-Related Macular Degeneration, 2014-04-29

• Absence of cytomegalovirus in glioblastoma and other high-grade gliomas by real-time PCR, immunohistochemistry andin situhybridization, 2016-12-29

• Recurrent somatic alterations ofFGFR1andNTRK2in pilocytic astrocytoma, 2013-06-30

• Astrocytic trans-differentiation completes a multicellular paracrine feedback loop required for medulloblastoma tumor growth, 2020-01-23

• Genetic Profiling by Single-Nucleotide Polymorphism-Based Array Analysis Defines Three Distinct Subtypes of Orbital Meningioma, 2014-05-21

• Embryonal Tumors With Abundant Neuropil and True Rosettes A Distinctive CNS Primitive Neuroectodermal Tumor, 2015-07-17

• Targeting Notch signaling as a novel therapy for retinoblastoma, 2016-09-20

• Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia-reperfusion injury, 2011-04-19

• Multi-faceted computational assessment of risk and progression in oligodendroglioma implicates NOTCH and PI3K pathways, 2018-11-06

• Downregulation of Nodal inhibits metastatic progression in retinoblastoma, 2019-08-26

• Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma, 2009-03-08

• DNA Fragmentation Simulation Method (FSM) and Fragment Size Matching Improve aCGH Performance of FFPE Tissues, 2012-06-15

• Regulation of sonic hedgehog-GLI1downstream target genesPTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2and their epigenetic status in medulloblastoma and astrocytoma, 2010-11-08

• Controlled release of dexamethasone sodium phosphate with biodegradable nanoparticles for preventing experimental corneal neovascularization, 2019-01-21

• A model of a patient-derivedIDH1mutant anaplastic astrocytoma with alternative lengthening of telomeres, 2014-12-04

• Correction to: Medulloblastoma cerebrospinal fluid reveals metabolites and lipids indicative of hypoxia and cancer-specific RNAs, 2022-04-22

• Clinicopathologic implications ofNF1gene alterations in diffuse gliomas, 2015-05-30

• Human hedgehog interacting protein expression and promoter methylation in medulloblastoma cell lines and primary tumor samples, 2010-09-19

• Amide Proton Transfer-Weighted MR Image-Guided Stereotactic Biopsy in Patients with Newly Diagnosed Gliomas, 2017-07-10

• c-MYC expression sensitizes medulloblastoma cells to radio- and chemotherapy and has no impact on response in medulloblastoma patients, 2011-02-16

• Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors, 2022-04-28

• Growth properties of SF188/V+ human glioma in rats in vivo observed by magnetic resonance imaging, 2012-09-27

• Bioreducible polymeric nanoparticles containing multiplexed cancer stem cell-regulating miRNAs inhibit glioblastoma growth and prolong survival, 2018-06-28

• Integrated molecular and clinical analysis of BRAF-mutant glioma in adults, 2023-02-28

• Radiomics analysis of amide proton transfer-weighted and structural MR images for treatment response assessment in malignant gliomas, 2022-09-24

• Rosette forming glioneuronal tumor in association with Noonan syndrome:mechanistic implications, 2013-04-05

• Corticosteroid-loaded biodegradable nanoparticles for prevention of corneal allograft rejection in rats, 2015-01-08

• Morphologic characteristics and immunohistochemical profile of diffuse intrinsic pontine gliomas, 2013-06-07

• The dual mTOR kinase inhibitor TAK228 inhibits tumorigenicity and enhances radiosensitization in diffuse intrinsic pontine glioma, 2017-04-25

• mTORC1-Mediated Inhibition of 4EBP1 is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma, 2017-11-02

• cMYC Expression in Infiltrating Gliomas: Associations withIDH1Mutations, Clinicopathologic Features and Outcome, 2013-08-11

• Combination of paclitaxel thermal gel depot with temozolomide and radiotherapy significantly prolongs survival in an experimental rodent glioma model, 2012-12-07

• Correction: Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma, 2021-03-02

• Recurrent homozygous deletion ofDROSHAand microduplication ofPDE4DIPin pineoblastoma, 2018-07-20

• Medulloblastoma cerebrospinal fluid reveals metabolites and lipids indicative of hypoxia and cancer-specific RNAs, 2022-02-24

• Comprehensive Metabolic Profiling of MYC-Amplified Medulloblastoma Tumors Reveals Key Dependencies on Amino Acid, Tricarboxylic Acid and Hexosamine Pathways, 2022-03-03

• An Update on Endocrine Mucin-Producing Sweat Gland Carcinoma: Clinicopathologic Study of 63 Cases and Comparative Analysis, 2020-02-22