Dr. Eugene Chang, MD

• Gastroenterology

• Internal Medicine

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• University Of Chicago

  Medical School, 1976

• The Gut Microbiota and Inflammatory Bowel Diseases, 2016-06-14

• Exercise Prevents Weight Gain and Alters the Gut Microbiota in a Mouse Model of High Fat Diet-Induced Obesity, 2014-03-26

• Diet, gut microbes, and genetics in immune function: Can we leverage our current knowledge to achieve better outcomes in inflammatory bowel diseases?, 2014-09-15

• Dynamic genetic adaptation ofBacteroides thetaiotaomicronduring murine gut colonization, 2023-08-21

• High-Fat Diet Alters the Retinal Transcriptome in the Absence of Gut Microbiota, 2021-08-18

• Determination of American ginseng saponins and their metabolites in human plasma, urine and feces samples by liquid chromatography coupled with quadrupole time-of-flight mass spectrometry, 2016-02-06

• Early-life microbial restitution reduces colitis risk promoted by antibiotic-induced gut dysbiosis in IL-10-/-mice, 2021-06-07

• Gut microbiota modulates bleomycin-induced acute lung injury response in mice, 2022-12-10

• Angiotensin II directly regulates intestinal epithelial NHE3 in Caco2BBE cells, 2009-04-01

• Bacteria-Free Solution Derived fromLactobacillus plantarumInhibits Multiple NF-KappaB Pathways and Inhibits Proteasome Function, 2009-07-07

• Significant difference in active metabolite levels of ginseng in humans consuming Asian or Western diet: the link of enteric microbiota, 2016-10-13

• Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10 producing T-cells, 2013-08-16

• Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development, 2016-08-26

• CommensalBifidobacteriumpromotes antitumor immunity and facilitates anti-PD-L1 efficacy, 2015-11-05

• Transplanting a Microbial Organ: the Good, the Bad, and the Unknown, 2016-05-03

• Michael addition-based probes for ratiometric fluorescence imaging of proteinS-depalmitoylases in live cells and tissues† †Electronic supplementary information (ESI) available: Materials and methods, synthetic procedures, supplementary figures and data. See DOI: 10.1039/c7sc02805a, 2017-09-11

• Patient-SpecificBacteroidesGenome Variants in Pouchitis Vineis et al., 2016-11-15

• High-fat diet disrupts REG3? and gut microbial rhythms promoting metabolic dysfunction, 2022-04-18

• Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APCmin/+Mouse Models of Experimental Colon Cancer, 2016-10-12

• Human microbiome science: vision for the future, Bethesda, MD, July 24 to 26, 2013, 2014-07-18

• Intersection of the Gut Microbiome and Circadian Rhythms in Metabolism, 2019-10-31

• Hepatocyte specific HMGB1 deletion worsens the injury in liver ischemia/reperfusion: A role for intracellular HMGB1 in cellular protection, 2014-04-01

• Time-, Sex-, and Dose-Dependent Alterations of the Gut Microbiota by Consumption of Dietary Daikenchuto (TU-100), 2018-02-22

• Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease, 2016-07-21

• Microbial signals drive pre-leukaemic myeloproliferation in aTet2-deficient host, 2018-05-16

• Bile Diversion Improves Metabolic Phenotype Dependent on Farnesoid X Receptor (FXR), 2019-04-01

• Droplet-based high-throughput cultivation for accurate screening of antibiotic resistant gut microbes, 2020-06-17

• Regional Mucosa-Associated Microbiota Determine Physiological Expression of TLR2 and TLR4 in Murine Colon, 2010-10-22

• Cytokine Regulation of OCTN2 Expression and Activity in Small and Large Intestine, 2010-08-18

• Role of intestinal microbiome in American ginseng-mediated colon cancer protection in high fat diet-fed AOM/DSS mice, 2017-08-14

• TU-100 (Daikenchuto) and Ginger Ameliorate Anti-CD3 Antibody Induced T Cell-Mediated Murine Enteritis: Microbe-Independent Effects Involving Akt and NF-?B Suppression, 2014-05-23

• Lubiprostone Decreases Mouse Colonic Inner Mucus Layer Thickness and Alters Intestinal Microbiota, 2013-01-18

• American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR, 2011-11-09

• Exploring gut microbes in human health and disease: Pushing the envelope, 2014-08-09

• Intracellular Hmgb1 Inhibits Inflammatory Nucleosome Release and Limits Acute Pancreatitis in Mice, 2013-12-17

• Genetic and metabolic signals during acute enteric bacterial infection alter the microbiota and drive progression to chronic inflammatory disease, 2016-01-13

• Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases, 2015-01-20

• Small intestine microbiota regulate host digestive and absorptive adaptive responses to dietary lipids, 2018-04-11

• Plasma microbiome-modulated indole- and phenyl-derived metabolites associate with advanced atherosclerosis and post-operative outcomes, 2017-12-13

• Gnotobiotic Operations and Assembly for Development of Germ-Free Animal Model of Laser-Induced Choroidal Neovascularization, 2021-08-13

• Ultra-Performance Liquid Chromatography and Time-of-Flight Mass Spectrometry Analysis of Ginsenoside Metabolites in Human Plasma, 2011-10-26

• Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation, 2018-11-13

• Fructose diet alleviates acetaminophen-induced hepatotoxicity in mice, 2017-08-23

• Atypical behavioral and thermoregulatory circadian rhythms in mice lacking a microbiome, 2022-08-25

• Bacterial community structure and functional contributions to emergence of health or necrotizing enterocolitis in preterm infants, 2013-07-10

• Laser capture microdissection and metagenomic analysis of intact mucosa-associated microbial communities of human colon, 2010-10-08

• Effects of diurnal variation of gut microbes and high fat feeding on host circadian clock function and metabolism, 2015-04-16

• 16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis, 2009-04-16

• miR-143 and miR-145 are down-regulated in ulcerative colitis: putative regulators of inflammation and protooncogenes, 2011-05-06

• Multiphasic analysis of the temporal development of the distal gut microbiota in patients following ileal pouch anal anastomosis, 2013-03-04

• The Microbe-Derived Short Chain Fatty Acid Butyrate Targets miRNA-Dependent p21 Gene Expression in Human Colon Cancer, 2011-01-20

• Minimizing confounders and increasing data quality in murine models for studies of the gut microbiome, 2018-07-12

• Mutual reinforcement of pathophysiological host-microbe interactions in intestinal stasis models, 2017-03-21

• Comparison of brush and biopsy sampling methods of the ileal pouch for assessment of mucosa-associated microbiota of human subjects, 2014-02-14

• The Gut Microbiome and Inflammatory Bowel Diseases, 2021-09-23

• The microbiome: composition and locations, 2020-09-24

• Gut microbes and the liver circadian clock partition glucose and lipid metabolism, 2023-09-15

• Microbiota control acute arterial inflammation and neointimal hyperplasia development after arterial injury, 2018-12-06

• Correction: Michael addition-based probes for ratiometric fluorescence imaging of proteinS-depalmitoylases in live cells and tissues, 2017-10-12

• Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice, 2016-10-14

• Report of the National Heart, Lung, and Blood Institute Working Group on the Role of Microbiota in Blood Pressure Regulation: Current Status and Future Directions, 2017-07-31

• Interactions between diet, bile acid metabolism, gut microbiota, and Inflammatory Bowel Diseases, 2015-05-27

• Bile acid fitness determinants of aBacteroides fragilisisolate from a human pouchitis patient, 2023-10-17

• Antibiotics Suppress Activation of Intestinal Mucosal Mast Cells and Reduce Dietary Lipid Absorption in Sprague-Dawley Rats, 2016-07-18

• Early transcriptomic changes in the ileal pouch provide insight into the molecular pathogenesis of pouchitis and ulcerative colitis, 2017-10-10

• How to improve a human gut microbiome study: Pathway to success from lessons learned, 2020-09-07

• Microbiome characterization by high-throughput transfer RNA sequencing and modification analysis, 2018-12-17

• A Multifunctional Neutralizing Antibody-Conjugated Nanoparticle Inhibits and Inactivates SARS-CoV-2, 2021-11-10

• Regional Diversity of the Gastrointestinal Microbiome, 2019-09-11

• Intestinal epithelial vitamin D receptor deletion leads to defective autophagyin colitis, 2014-07-30

• The Colitis-Associated Transcriptional Profile of CommensalBacteroides thetaiotaomicronEnhances Adaptive Immune Responses to a Bacterial Antigen, 2012-08-03

• Absence of Gut Microbiota Is Associated with RPE/Choroid Transcriptomic Changes Related to Age-Related Macular Degeneration Pathobiology and Decreased Choroidal Neovascularization, 2022-08-26

• Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions, 2013-01-31

• High-Fat Diet Alters the Retinal Pigment Epithelium and Choroidal Transcriptome in the Absence of Gut Microbiota, 2022-06-30

• Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1?E9murine model of Alzheimer's disease, 2017-09-05

• Microbiota composition modulates inflammation and neointimal hyperplasia after arterial angioplasty, 2020-02-05

• A highly conserved and globally prevalent cryptic plasmid is among the most numerous mobile genetic elements in the human gut, 2023-03-25

• A gene-targeted approach to investigate the intestinal butyrate-producing bacterial community, 2013-03-04

• Transcriptional Modulation of Intestinal Innate Defense/Inflammation Genes by Preterm Infant Microbiota in a Humanized Gnotobiotic Mouse Model, 2015-04-30

• Dietary fat-induced taurocholic acid production promotes pathobiont and colitis in IL-10-/-mice, 2012-07-05

• Divergent responses of viral and bacterial communities in the gut microbiome to dietary disturbances in mice, 2015-10-16

• Evolutionary and ecological forces that shape the bacterial communities of the human gut, 2017-02-01