Dr. Howard Chang, MD

• Dermatology

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• Stanford University

  Residency Hospital, 2004

• Stanford Hospital

  Fellowship Hospital, 2004

• Santa Clara Valley Medical Center

  Internship Hospital, 2001

• Harvard Medical School

  Medical School, 2000

• HOXC10 expression supports the development of chemotherapy resistance by fine tuning DNA repair in breast cancer cells, 2016-06-14

• DDX5 and its associated lncRNA Rmrp modulate Th17 cell effector functions, 2015-12-16

• Extensive and coordinated transcription of noncoding RNAs within cell cycle promoters, 2011-06-05

• Factors That May Promote an Effective Local Research Environment, 2018-03-14

• Generation of pure GABAergic neurons by transcription factor programming, 2017-05-15

• Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements, 2017-09-25

• Gpr124 is essential for blood-brain barrier integrity in central nervous system disease, 2017-03-13

• AnNfil3-Zeb2-Id2pathway imposesIrf8enhancer switching during cDC1 development, 2019-08-12

• Cerebellar nuclei evolved by repeatedly duplicating a conserved cell-type set, 2020-12-18

• Profiling chromatin accessibility responses in human neutrophils with sensitive pathogen detection, 2021-06-18

• Human B cell clonal expansion and convergent antibody responses to SARS-CoV-2, 2020-09-03

• Single-cell epigenomic variability reveals functional cancer heterogeneity, 2017-01-24

• Identification of a Selective Polymerase Enables Detection of N6-methyladenosine in RNA, 2013-12-11

• Single-cell profiling of lncRNAs in the developing human brain, 2016-04-14

• Chromatin accessibility landscape of cutaneous T cell lymphoma and dynamic response to HDAC inhibitors, 2017-06-15

• Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia, 2020-02-06

• A long noncoding RNA lincRNA-EPS acts as a transcriptional brake to restrain inflammation, 2016-06-16

• Discovery of stimulation-responsive immune enhancers with CRISPR activation, 2017-08-30

• Targeted disruption ofHotairleads to homeotic transformation and gene de-repression, 2013-09-26

• BRD2 Compartmentalizes the Accessible Genome, 2022-04-11

• Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers, 2012-08-28

• Preleukemic Hematopoietic Stem Cells in Human Acute Myeloid Leukemia, 2017-11-06

• An activity switch in human telomerase based on RNA conformation and shaped by TCAB1, 2018-05-24

• HiChIP: Efficient and sensitive analysis of protein-directed genome architecture, 2016-09-19

• Comment on "HotairIs Dispensable for Mouse Development", 2016-12-15

• A Transcriptional Program Mediating Entry into Cellular Quiescence, 2007-06-08

• LncRNA-HITFunctions as an Epigenetic Regulator of Chondrogenesis through Its Recruitment of p100/CBP Complexes, 2015-12-03

• Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility, 2022-01-31

• Detecting riboSNitches with RNA folding algorithms: a genome-wide benchmark, 2015-01-23

• Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen, 2020-07-13

• A MUTATION IN THE TRANSCRIPTION FACTORFOXP3DRIVES T HELPER 2 EFFECTOR FUNCTION IN REGULATORY T CELLS, 2019-01-29

• A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics, 2013-07-23

• Chromatin Landscape Underpinning Human Dendritic Cell Heterogeneity, 2020-09-22

• Chromatin accessibility associates with protein-RNA correlation in human cancer, 2021-09-30

• The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression, 2012-05-10

• Systematic discovery of Xist RNA binding proteins, 2015-04-02

• Functional significance of U2AF1 S34F mutations in lung adenocarcinomas, 2019-12-13

• The Mettl3 epitranscriptomic writer amplifies p53 stress responses, 2022-05-04

• Novel Gene Expression Profile of Women with Intrinsic Skin Youthfulness by Whole Transcriptome Sequencing, 2016-11-09

• Age-dependent pancreatic gene regulation reveals mechanisms governing human ß-cell function, 2016-04-28

• Domain ChIRP reveals the modularity of long noncoding RNA architecture, chromatin interactions, and function, 2014-07-06

• Augmenting Endogenous Wnt Signaling Improves Skin Wound Healing, 2013-10-18

• Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation, 2020-05-07

• Systematic reconstruction of RNA functional motifs with high throughput microfluidics, 2012-11-11

• Cryptic activation of anIrf8enhancer governs cDC1 fate specification, 2019-08-12

• Tumor suppression by the histone demethylase UTX, 2010-06-01

• The AAV capsid can influence the epigenetic marking of rAAV delivered episomal genomes in a species dependent manner, 2023-04-28

• m6A RNA modification controls cell fate transition in mammalian embryonic stem cells, 2014-10-16

• Direct lineage conversion of terminally differentiated hepatocytes to functional neurons, 2011-09-29

• Epigenomics-Technologies and Applications, 2018-04-27

• CD44+cells in head and neck squamous cell carcinoma suppress T cell-mediated immunity by selective constitutive and inducible expression of PD-L1, 2016-02-10

• Integrative genomic analysis by interoperation of bioinformatics tools in GenomeSpace, 2016-01-18

• Whole genome deconvolution unveils Alzheimer's resilient epigenetic signature, 2023-08-16

• Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer's and Parkinson's diseases, 2020-10-26

• Single-cell chromatin accessibility reveals principles of regulatory variation, 2015-06-17

• Challenges and recommendations for epigenomics in precision health, 2017-12-08

• Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency, 2014-02-12

• Genome-wide measurement of RNA folding energies, 2012-09-13

• Author Correction: Engineering circular RNA for enhanced protein production, 2022-08-17

• Single-cell RNA sequencing in cardiovascular development, disease and medicine, 2020-03-30

• HiChIRP reveals RNA-associated chromosome conformation, 2019-05-27

• High throughput automated chromatin immunoprecipitation as a platform for drug screening and antibody validation, 2012-05-08

• Inducible lncRNA transgenic mice reveal continual role ofHOTAIRin promoting breast cancer metastasis, 2022-12-29

• Enhanced safety and efficacy of protease-regulated CAR-T cell receptors, 2022-04-27

• Extrachromosomal DNA in the cancerous transformation of Barrett's oesophagus, 2023-04-12

• Rapid evolutionary turnover underlies conserved lncRNA-genome interactions Rapid evolution of lncRNA-binding sites, 2016-01-15

• Lineage-specific dynamic and pre-established enhancer-promoter contacts cooperate in terminal differentiation, 2017-08-14

• NeST, a long noncoding RNA, controls microbial susceptibility and epigenetic activation of theIfnglocus, 2013-02-14

• 3D ATAC-PALM: Super-resolution Imaging of the Accessible Genome, 2020-03-16

• Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity, 2018-11-02

• Expression of the transcription factor ZBTB46 distinguishes human histiocytic disorders of classical dendritic cell origin, 2018-05-09

• HOXA3 Modulates Injury-Induced Mobilization and Recruitment of Bone Marrow-Derived Cells, 2009-07-01

• Identification of the Human Skeletal Stem Cell, 2018-09-20

• RNA Structural Analysis by Evolving SHAPE Chemistry, 2014-08-15

• Analysis of RNA conformation in endogenously assembled RNPs by icSHAPE, 2021-04-28

• Subcellular Spatial Transcriptomes: Emerging Frontier for Understanding Gene Regulation, 2020-06-01

• Structural modularity of the XIST ribonucleoprotein complex, 2020-12-02

• Chromatin accessibility dynamics in a model of human forebrain development, 2020-01-24

• CRISPRi-based genome-scale identification of functional long non-coding RNA loci in human cells, 2016-12-15

• Anatomic Demarcation by Positional Variation in Fibroblast Gene Expression Programs, 2006-07-28

• Sensing Self and Foreign Circular RNAs by Intron Identity, 2017-06-15

• Stress from nucleotide depletion activates the transcriptional regulator HEXIM1 to suppress melanoma, 2016-04-07

• Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells, 2023-05-04

• Genome-wide Measurement of RNA Secondary Structure in Yeast, 2010-09-02

• Molecular Framework for Response to Imatinib Mesylate in Systemic Sclerosis, 2009-01-09

• Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis, 2010-04-15

• Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration, 2018-10-24

• KLF4 recruits SWI/SNF to increase chromatin accessibility and reprogram the endothelial enhancer landscape under laminar shear stress, 2022-08-23

• B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells, 2021-03-17

• Long Noncoding RNAs: At the Intersection of Cancer and Chromatin Biology, 2017-07-05

• Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH, 2022-10-17

• Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock, 2012-01-20

• ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation, 2009-01-30

• Tracking the immune response with single-cell genomics, 2019-12-16

• The dynamic, combinatorialcis-regulatory lexicon of epidermal differentiation, 2021-10-14

• Circular RNA vaccine induces potent T cell responses, 2023-05-08

• Extrachromosomal DNA: An Emerging Hallmark in Human Cancer, 2021-11-09

• Global Expression Profiling in Atopic Eczema Reveals Reciprocal Expression of Inflammatory and Lipid Genes, 2008-12-24

• RNA duplex map in living cells reveals higher order transcriptome structure, 2016-05-12

• Tumor Vasculature is Regulated by PHD2-mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment, 2009-06-02

• Hierarchical mechanisms for transcription factor-mediated reprogramming of fibroblasts to neurons, 2013-10-24

• Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds, 2004-01-13

• A chromatin basis for cell lineage and disease risk in the human pancreas, 2018-08-22

• Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptional Networks, 2011-06-30

• GPC2-CAR T Cells Tuned for Low Antigen Density Mediate Potent Activity Against Neuroblastoma Without Toxicity., 2021-12-30

• Control of somatic tissue differentiation by the long non-coding RNA TINCR, 2012-12-02

• Retinoic Acid and BMP4 Cooperate with TP63 to alter Chromatin Dynamics during Surface Epithelial Commitment, 2018-11-05

• Genome-Wide Views of Chromatin Structure, 2010-01-11

• Author Correction: ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis, 2021-03-31

• GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways, 2019-10-31

• Systematic discovery and functional interrogation of SARS-CoV-2 viral RNA-host protein interactions during infection, 2020-10-06

• Structural organization of the inactive X chromosome in the mouse, 2016-07-18

• Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNA, 2019-04-09

• Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes, 2010-07-08

• RNA helicase DDX21 coordinates transcription and ribosomal RNA processing, 2014-11-24

• HOXB13 Mediates Tamoxifen Resistance and Invasiveness in Human Breast Cancer by Suppressing ERa and Inducing IL-6 Expression, 2013-07-05

• RNA SHAPE analysis in living cells, 2012-11-25

• m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway, 2017-08-09

• Predicting a local recurrence after breast-conserving therapy by gene expression profiling, 2006-10-30

• A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells, 2020-05-13

• BABEL enables cross-modality translation between multiomic profiles at single-cell resolution, 2021-04-07

• Structural imprintsin vivodecode RNA regulatory mechanisms, 2015-03-18

• Hierarchical maintenance ofMLLmyeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells, 2009-02-06

• The role ofXist-mediated Polycomb recruitment in the initiation of X-chromosome inactivation, 2019-08-27

• Dynamic chromatin regulatory landscape of human CAR T cell exhaustion, 2021-07-20

• JUN promotes hypertrophic skin scarring via CD36 in preclinical in vitro and in vivo models, 2021-09-01

• The evolutionary dynamics of extrachromosomal DNA in human cancers, 2022-09-19

• An inducible long noncoding RNA amplifies DNA damage signaling, 2016-09-26

• Genome regulation by long noncoding RNAs, 2013-12-01

• Long intergenic non-coding RNAs - New links in cancer progression, 2011-01-01

• Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis, 2020-11-10

• Genome-wide Programmable Transcriptional Memory by CRISPR-based Epigenome Editing, 2021-04-09

• 7SK-BAF axis controls pervasive transcription at enhancers, 2016-02-15

• Detection of Long Non-Coding RNA in Archival Tissue: Correlation with Polycomb Protein Expression in Primary and Metastatic Breast Carcinoma, 2012-10-25

• ecDNA hubs drive cooperative intermolecular oncogene expression, 2021-11-24

• The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1, 2022-12-27

• Molecular and Neural Functions ofRai1, The Causal Gene for Smith-Magenis Syndrome, 2016-09-29

• Transcript-indexed ATAC-seq for precision immune profiling, 2018-04-23

• Engineering circular RNA for enhanced protein production, 2022-07-18

• Lineage-specific and single cell chromatin accessibility charts human hematopoiesis and leukemia evolution, 2016-08-15

• irCLIP platform for efficient characterization of protein-RNA interactions, 2016-04-25

• Identification of proteins binding coding and non-coding human RNAs using protein microarrays, 2012-11-16

• A novel ATAC-seq approach reveals lineage-specific reinforcement of the open chromatin landscape via cooperation between BAF and p63, 2015-12-18

• Deletional Tolerance Mediated by Extrathymic Aire-Expressing Cells*, 2008-08-08

• Noncoding RNAs: biology and applications-a Keystone Symposia report, 2021-11-17

• Combining biological gene expression signatures in predicting outcome in breast cancer: An alternative to supervised classification, 2008-08-18

• Footprinting SHAPE-eCLIP reveals transcriptome-wide hydrogen bonds at RNA-protein interfaces, 2020-11-25

• Oncogene convergence in extrachromosomal DNA hubs, 2022-05-02

• Structure and Thermodynamics of N6-Methyladenosine in RNA: A Spring-Loaded Base Modification, 2015-02-02

• Long Noncoding RNAs in Cancer Pathways, 2016-04-11

• Transposition of native chromatin for multimodal regulatory analysis and personal epigenomics, 2013-10-06

• An Integrated Cell Purification and Genomics Strategy Reveals Multiple Regulators of Pancreas Development, 2014-10-16

• Transcriptome-wide interrogation of RNA secondary structure in living cells with icSHAPE, 2016-01-14

• Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions, 2019-07-19

• N6-methyladenosine modification controls circular RNA immunity, 2019-08-29

• Genomic maps of lincRNA occupancy reveal principles of RNA-chromatin interactions, 2011-09-29

• The chromatin accessibility landscape of primary human cancers, 2018-10-26

• Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia, 2019-12-02

• Transient "rest” restores functionality in exhausted CAR-T cells via epigenetic remodeling, 2021-04-02

• ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis, 2021-02-25

• RNA structure maps across mammalian cellular compartments, 2019-03-18

• Clonal replacement of tumor-specific T cells following PD-1 blockade, 2019-07-29

• Enhanced T Cell Effector Activity by Targeting Mediator Kinase Module, 2022-11-11

• The histone chaperone CAF-1 safeguards somatic cell identity, 2015-12-10

• Promoter of lncRNA genePVT1is a tumor suppressor DNA boundary element, 2018-05-03

• Long noncoding RNAs in cell fate programming and reprogramming, 2014-06-05

• Genome-Wide Temporal Profiling of Transcriptome and Open-Chromatin of Early Cardiomyocyte Differentiation Derived From hiPSCs and hESCs, 2017-06-29

• Landscape of monoallelic DNA accessibility in mouse embryonic stem cells and neural progenitor cells, 2017-01-23

• Landscape and variation of RNA secondary structure across the human transcriptome, 2014-01-30

• ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing, 2016-10-17

• Endogenous Retrovirus-Derived lncRNABANCRPromotes Cardiomyocyte Migration in Humans and Non-human Primates, 2020-08-06

• Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress, 2016-04-05

• Gene regulation on extrachromosomal DNA, 2022-08-10

• Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers, 2020-08-17

• SIRT6 links histone H3 lysine 9 deacetylation to control of NF-?B dependent gene expression and organismal lifespan, 2009-01-09

• Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis, 2020-11-17

• Rapid chromatin switch in the direct reprogramming of fibroblasts to neurons, 2017-09-26

• Individuality and variation of personal regulomes in primary human T cells, 2015-07-29

• Single-cell multiome of the human retina and deep learning nominate causal variants in complex eye diseases, 2022-07-27

• Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders, 2018-01-24

• TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment, 2019-01-24

• Systematic Characterization of Long Non-Coding RNAs Reveals the Contrasting Coordination of Cis- and Trans- Molecular Regulation in Human Fetal and Adult Heart, 2016-02-19

• Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion, 2019-08-02

• Single-cell analyses identify brain mural cells expressing CD19 as potential off-tumor targets for CAR-T immunotherapies., 2020-09-21

• PIRCh-seq: functional classification of non-coding RNAs associated with distinct histone modifications, 2019-12-20

• Coupled single-cell CRISPR screening and epigenomic profiling reveals causal gene regulatory networks, 2018-12-20

• Integrated spatial multiomics reveals fibroblast fate during tissue repair, 2021-10-07

• An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues, 2017-08-28

• Regeneration, repair and remembering identity: the three Rs ofHoxgene expression, 2009-05-08

• Leukemia-associated cohesin mutants dominantly enforce stem cell programs and impair human hematopoietic progenitor differentiation, 2015-10-22

• Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions, 2021-04-29

• Modeling Inducible Human Tissue Neoplasia Identifies an Extracellular Matrix Interaction Network Involved in Cancer Progression, 2009-06-02

• Activation of PDGF Pathway Links LMNA Mutation to Dilated Cardiomyopathy, 2019-07-17

• Rapid chromatin repression by Aire provides precise control of immune tolerance, 2018-01-15

• Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells, 2015-04-20

• Transcription coactivator and lncRNA duet evoke Hox genes, 2017-06-29

• Fitness effects of CRISPR/Cas9-targeting of long non-coding RNA genes, 2020-02-24

• Genome-Wide Analysis of KAP1 Binding Suggests Autoregulation of KRAB-ZNFs, 2007-06-01

• Structured elements drive extensive circular RNA translation, 2021-08-25

• Long noncoding RNA programs active chromatin domain to coordinate homeotic gene activation, 2011-03-20

• Oncogene Convergence in Extrachromosomal DNA Hubs, 2022-04-10

• Comparison of SHAPE reagents for mapping RNA structures inside living cells Comparison of in vivo SHAPE probes, 2017-02-01

• Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation, 2022-05-26

• Atlas of Subcellular RNA Localization Revealed by APEX-seq, 2019-06-20

• Circular ecDNA promotes accessible chromatin and high oncogene expression, 2019-11-20

• Author Correction: Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis, 2020-12-14

• A TGFß-Responsive Gene Signature Is Associated with a Subset of Diffuse Scleroderma with Increased Disease Severity, 2009-10-08

• Locus specific epigenetic modalities of random allelic expression imbalance, 2021-09-09

• The mammalian ribo-interactome reveals ribosome functional diversity and heterogeneity, 2017-06-01

• Dicer-microRNA-Myc circuit promotes transcription of hundreds of long noncoding RNAs, 2014-06-15

• Tandem Stem Loops in roX RNAs Act Together to Mediate X Chromosome Dosage Compensation inDrosophila, 2013-07-25

• Genetic determinants of co-accessible chromatin regions in activated T cells across humans, 2018-07-09

• Integrated single-cell analysis maps the continuous regulatory landscape of human hematopoietic differentiation, 2018-04-26

• Circular RNA migration in agarose gel electrophoresis, 2022-03-30

• Quantitative analysis of RNA-protein interactions on a massively parallel array for mapping biophysical and evolutionary landscapes, 2014-04-13

• LKB1 inactivation modulates chromatin accessibility to drive metastatic progression, 2021-08-02

• RNA-binding proteins direct myogenic cell fate decisions, 2022-06-13