Dr. James Kirkland, MD

• Geriatric Medicine

• Endocrinology, Diabetes & Metabolism

• Internal Medicine

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• University Of Toronto Faculty Of Medicine

  Medical School

• Selective Vulnerability of Senescent Glioblastoma Cells to BCL-XL Inhibition, 2022-06-03

• Senolytics reduce coronavirus-related mortality in old mice, 2021-06-08

• Targeted clearance ofp21- but notp16-positive senescent cells prevents radiation-induced osteoporosis and increased marrow adiposity, 2022-04-01

• Corrigendum to ‘Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease' EBioMedicine 47 (2019) 446-456, 2020-01-23

• Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance, 2022-09-27

• Fat Tissue, Aging, and Cellular Senescence, 2010-08-15

• Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice, 2020-01-18

• Beta-Mecaptoethanol Suppresses Inflammation and Induces Adipogenic Differentiation in 3T3-F442A Murine Preadipocytes, 2012-07-23

• Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia, 2019-09-14

• SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3, 2021-09-16

• Cellular senescence and senolytics: the path to the clinic, 2022-08-11

• Challenges in developing Geroscience trials, 2023-08-19

• Role of microRNA Processing in Adipose Tissue in Stress Defense and Longevity, 2012-09-05

• Impact of Senescent Cell Subtypes on Tissue Dysfunction and Repair, 2021-08-02

• Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis, 2019-05-07

• INCREASED CELLULAR SENESCENCE IN THE MURINE AND HUMAN STENOTIC KIDNEY: EFFECT OF MESENCHYMAL STEM CELLS, 2020-07-13

• Testosterone Plus Low-Intensity Physical Training in Late Life Improves Functional Performance, Skeletal Muscle Mitochondrial Biogenesis, and Mitochondrial Quality Control in Male Mice, 2012-12-11

• Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/- mice, 2015-06-29

• Senescent Cells: A Therapeutic Target in Cardiovascular Diseases, 2023-05-02

• Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue, 2020-08-28

• An induciblep21-Cre mouse model to monitor and manipulatep21-highly-expressing senescent cellsin vivo, 2021-10-07

• Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice, 2014-07-20

• Fisetin for COVID-19 in Skilled Nursing Facilities (COVID-FIS): Senolytic Trials in the COVID Era, 2021-08-20

• Sex- and depot-dependent differences in adipogenesis in normal weight humans, 2010-03-18

• Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities, 2020-10-19

• Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex, 2023-05-22

• Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice, 2021-01-20

• Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation, 2020-08-27

• Cellular Senescence and the Biology of Aging, Disease, and Frailty, 2015-10-20

• Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases, 2020-04-06

• A chronic wound model to investigate skin cellular senescence, 2023-04-21

• Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease, 2019-09-18

• Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors, 2016-03-18

• CELLULAR SENESCENCE AS A THERAPEUTIC TARGET FOR GEROSCIENCE-GUIDED CLINICAL TRIALS, 2019-11-08

• Growth hormone receptor antagonist (GHA) transgenic mice have increased subcutaneous adipose tissue mass, altered glucose homeostasis, and no change in white adipose tissue cellular senescence, 2015-09-16

• Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice, 2016-08-05

• CD38 ecto-enzyme in immune cells is induced during aging regulating NAD+and NMN levels, 2020-11-16

• The role of cellular senescence in ageing and endocrine disease, 2020-03-11

• Length-independent telomere damage drives post-mitotic cardiomyocyte senescence, 2019-02-08

• Deleted in Breast Cancer 1 regulates cellular senescence during obesity, 2014-07-03

• Strategies for Late Phase Preclinical and Early Clinical Trials of Senolytics, 2021-10-23

• The Clinical Potential of Senolytic Drugs, 2017-09-04

• Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner, 2021-03-25

• The Achilles' heel of senescent cells: from transcriptome to senolytic drugs, 2015-04-22

• Transplanting cells from old but not young donors causes physical dysfunction in older recipients, 2020-01-23

• Targetingp21Cip1-Highly-Expressing Cells in Adipose Tissue Alleviates Insulin Resistance in Obesity, 2021-11-22

• Aging and Adipose Tissue: Potential Interventions for Diabetes and Regenerative Medicine, 2016-02-26

• Cellular senescence in skin-related research: Targeted signaling pathways and naturally occurring therapeutic agents, 2023-04-11

• Quercetin Reverses Cardiac Systolic Dysfunction in Mice Fed with a High-Fat Diet: Role of Angiogenesis, 2021-02-19

• Senolytics Improve Physical Function and Increase Lifespan in Old Age, 2018-07-09

• Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling, 2016-08-09

• A stress-induced cilium-to-PML-NB route drives senescence initiation, 2023-04-03

• Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies, 2020-07-31

• A systems biology approach to the effect of aging, immunosenescence and vaccine response, 2014-05-13

• TRAIL RECEPTOR DELETION IN MICE SUPPRESSES THE INFLAMMATION OF NUTRIENT EXCESS, 2014-11-28

• IGF-I attenuates FFA-induced activation of JNK1 phosphorylation and TNFa expression in human subcutaneous preadipocytes, 2013-05-25

• In vitroandin vivoeffects of zoledronic acid on senescence and senescence-associated secretory phenotype markers, 2023-05-07

• Anti-Diabetic Effects of the Senolytic Agent Dasatinib, 2021-11-09

• Palmitate induces DNA damage and senescence in human adipocytesin vitrothat can be alleviated by oleic acid but not inorganic nitrate, 2022-04-04

• Selective kidney targeting increases the efficacy of mesenchymal stromal/stem cells for alleviation of murine stenotic-kidney senescence and damage, 2022-03-23

• Targeting senescent cholangiocytes and activated fibroblasts with Bcl-xL inhibitors ameliorates fibrosis in Mdr2-/-mice, 2017-11-29

• KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory Phenotype, 2021-05-13

• Targeting Cellular Senescence for Age-Related Diseases: Path to Clinical Translation, 2021-09-28

• Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span, 2020-09-30

• Extending human health span and longevity-a symposium report, 2021-09-08

• Aged-senescent cells contribute to impaired heart regeneration, 2019-03-10

• Effects of thiol antioxidant ß-mercaptoethanol on diet-induced obese mice, 2014-05-05

• Cell senescence, the senescence-associated secretory phenotype, and cancers, 2023-09-21

• Cellular senescence: at the nexus between ageing and diabetes, 2019-08-27

• Inflammatory Characteristics of Adipose Tissue Collected by Surgical Excisionvs.Needle Aspiration, 2014-10-16

• BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH, 2022-08-22

• Partial inhibition of mitochondrial complex I ameliorates Alzheimer's disease pathology and cognition in APP/PS1 female mice, 2021-01-08

• New agents that target senescent cells: the flavone, fisetin, and the BCL-XLinhibitors, A1331852 and A1155463, 2017-03-08

• Translating longevity research into healthspan, 2012-09-03

• Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells, 2020-03-26

• Increased Renal Cellular Senescence in Murine High-fat Diet: Effect of the Senolytic Drug Quercetin, 2019-07-15

• TNF -a/ IFN -? synergy amplifies senescence-associated inflammation and SARS-CoV -2 receptor expression via hyper-activated JAK / STAT1, 2022-05-30

• Senescent cell clearance by the immune system: Emerging therapeutic opportunities, 2019-05-11

• Meeting Report: Aging Research and Drug Discovery, 2022-01-28

• The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice, 2021-12-06

• Translating Advances from the Basic Biology of Aging into Clinical Application, 2012-12-10

• Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study, 2019-01-05

• Strategies for Targeting Senescent Cells in Human Disease, 2021-10-07

• A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues, 2022-08-16

• Accelerated Aging in Older Cancer Survivors, 2021-09-17

• Targeting senescent cells alleviates obesity-induced metabolic dysfunction, 2019-03-25

• Senescent Cells in Human Adipose Tissue: A Cross-Sectional Study, 2021-06-10

• Cellular senescence drives age-dependent hepatic steatosis, 2017-06-13