Dr. Jeffrey Rothstein, MD

• Neurology

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• The Johns Hopkins Hospital

  Residency Hospital, 1989

• Memorial Hosp-university Nc

  Internship Hospital, 1986

• University Of Illinois College Of Medicine

  Medical School, 1985

• Nuclear pore complexes - a doorway to neural injury in neurodegeneration, 2022-04-29

• Monocarboxylate transporter 1 in Schwann cells contributes to maintenance of sensory nerve myelination during aging, 2019-08-27

• Mutations in theMatrin 3gene cause familial amyotrophic lateral sclerosis, 2014-03-30

• Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS, 2021-07-28

• Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines, 2022-02-03

• Metabolic support of tumor-infiltrating regulatory T cells by lactic acid, 2021-02-15

• Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects, 2023-02-09

• Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export, 2022-07-19

• Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics - An AI-Enabled Biological Target Discovery Platform, 2022-06-28

• Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD, 2021-08-13

• Focal Transplantation-based Astrocyte Replacement is Neuroprotective in a Model of Motor Neuron Disease, 2008-10-19

• Mutant Huntingtin Disrupts the Nuclear Pore Complex, 2017-04-05

• Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis, 2013-03-31

• Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin, 2019-04-01

• A Helicase Unwinds Hexanucleotide Repeat RNA G-quadruplexes and Facilitates Repeat-associated Non-AUG Translation, 2021-04-15

• Nuclear lamina invaginations are not a pathological feature of C9orf72 ALS/FTD, 2021-03-19

• An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients, 2021-10-12

• G4C2repeat RNA initiates a POM121 mediated reduction in specific nucleoporins in C9orf72 ALS/FTD, 2020-07-15

• Tumor necrosis factor-a modulates glutamate transport in the CNS and is a critical determinant of outcome from viral encephalomyelitis, 2009-02-03

• CRISPR-Cas9 screens identify the RNA helicase DDX3X as a repressor ofC9ORF72(GGGGCC)n repeat-associated non-AUG translation, 2019-10-03

• UPF1 reducesC9orf72HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction, 2021-03-30

• Efficacy of local polymer-based and systemic delivery of the anti-glutamatergic agents riluzole and memantine in rat glioma models, 2014-01-31

• Zones of Enhanced Glutamate Release from Climbing Fibers in the Mammalian Cerebellum, 2010-05-26

• 3D Printer Generated Tissue iMolds for Cleared Tissue Using Single- and Multi-Photon Microscopy for Deep Tissue Evaluation, 2017-07-05

• The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei, 2021-07-19

• Astroglia in Thick Tissue with Super Resolution and Cellular Reconstruction, 2016-08-05

• MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal Degeneration, 2021-01-12

• The role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function in an iPSC model, 2019-07-15

• Polyadenylated RNA and RNA-Binding Proteins Exhibit Unique Response to Hyperosmotic Stress Hyperosmotic Stress Induces Nuclear Evacuation, 2021-12-14

• Oligodendroglia metabolically support axons and contribute to neurodegeneration, 2012-07-26

• Increased expression of glutamate transporter GLT-1 in peritumoral tissue associated with prolonged survival and decreases in tumor growth in a rat model of experimental malignant glioma Laboratory investigation, 2013-08-02

• Spatial and Temporal Changes in Promoter Activity of the Astrocyte Glutamate Transporter GLT1 Following Traumatic Spinal Cord Injury, 2011-04-12

• Reactive astrocyte nomenclature, definitions, and future directions, 2021-02-15

• C9orf72arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import, 2020-03-02

• Astrocyte Diversity: Current Insights and Future Directions, 2020-01-31

• RNA Is a Double-Edged Sword in ALS Pathogenesis, 2021-07-19