Dr. Keith Ligon, MD

• Neuropathology

• Anatomic Pathology

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• Brigham & Women's Hospital/boston Children's Hospital, Neuropathology

  Fellowship Hospital, 2009

• Brigham & Women's Hospital, Anatomic Pathology

  Residency Hospital, 1999

• University Of Texas Medical School At Houston, Graduate School

  1996

• Survival outcomes associated withMGMTpromoter methylation and temozolomide in gliosarcoma patients, 2022-04-26

• Neoplastic cells are a rare component in human glioblastoma microvasculature, 2012-01-30

• Implementing Patient-Derived Xenografts to Assess the Effectiveness of Cyclin-Dependent Kinase Inhibitors in Glioblastoma, 2019-12-12

• Reduced Levels of Misfolded and Aggregated Mutant p53 by Proteostatic Activation, 2023-03-21

• Preclinical efficacy of the MDM2 inhibitor RG7112 inMDM2amplified andTP53wild-type glioblastomas, 2015-10-19

• Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma, 2020-07-13

• Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma, 2019-06-03

• Calibrating genomic and allelic coverage bias in single-cell sequencing, 2015-04-16

• Tumor interferon signaling is regulated by a lncRNAINCR1transcribed from thePD-L1locus, 2020-06-05

• Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples, 2009-11-18

• G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells, 2017-02-13

• Subependymal giant cell astrocytomas are characterized by mTORC1 hyperactivation, a very low somatic mutation rate, and a unique gene expression profile, 2020-10-13

• Generation of patient-derived models from a metastatic pediatric diffuse leptomeningeal glioneuronal tumor withKIAA1549::BRAFfusion, 2022-08-04

• Dynamic BH3 profiling identifies pro-apoptotic drug combinations for the treatment of malignant pleural mesothelioma, 2023-05-20

• Somatic Mutations ofPIK3R1Promote Gliomagenesis, 2012-11-14

• Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial, 2018-12-19

• P53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation, 2008-10-23

• Absence of Oncogenic Canonical Pathway Mutations in Aggressive Pediatric Rhabdoid Tumors, 2012-09-19

• ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor initiating cell state, 2014-01-16

• Post-translational modifications of OLIG2 regulate glioma invasion through the TGFß pathway, 2016-07-07

• Linking single-cell measurements of mass, growth rate, and gene expression, 2018-11-27

• Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas, 2014-01-12

• Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma, 2020-11-25

• Intermediate DNA methylation is a conserved signature of genome regulation, 2015-02-18

• CRX Is a Diagnostic Marker of Retinal and Pineal Lineage Tumors, 2009-11-20

• Structural variants shape driver combinations and outcomes in pediatric high-grade glioma, 2022-07-04

• Improved Risk-Adjusted Survival for Melanoma Brain Metastases in the Era of Checkpoint Blockade Immunotherapies: Results from a National Cohort, 2018-07-12

• Human Glioma Growth is Controlled by MicroRNA-10b, 2011-04-06

• Case Report: Next generation sequencing identifies aNAB2-STAT6fusion in Glioblastoma, 2016-01-27

• DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape, 2013-05-26

• SHMT2 drives glioma cell survival in the tumor microenvironment but imposes a dependence on glycine clearance, 2015-04-08

• An integrative model of cellular states, plasticity and genetics for glioblastoma, 2019-07-18

• Dual HDAC and PI3K Inhibition Abrogates NF?B- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas, 2018-05-14

• Transformation by the R Enantiomer of 2-Hydroxyglutarate Linked to EglN Activation, 2012-02-15

• Effect of PIK3CA variants on glioma-related epilepsy and response to treatment, 2021-06-02

• Renal medullary carcinomas depend uponSMARCB1loss and are sensitive to proteasome inhibition, 2019-03-12

• Mechanisms and therapeutic implications of hypermutation in gliomas, 2020-04-15

• Mismatch repair deficiency in high-grade meningioma: a rare but recurrent event associated with dramatic immune activation and clinical response to PD-1 blockade, 2018-11-27

• Pediatric low-grade gliomas: How modern biology reshapes the clinical field, 2014-02-28

• Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy, 2013-09-04

• High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers, 2023-06-22

• Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development, 2008-04-08

• Brain and Testicular Tumors in Mice with Progenitor Cells Lacking BAX and BAK, 2012-09-17

• LONGITUDINAL MOLECULAR TRAJECTORIES OF DIFFUSE GLIOMA IN ADULTS, 2019-11-20

• miR-4516 predicts poor prognosis and functions as a novel oncogene via targetingPTPN14in human glioblastoma, 2018-12-17

• Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells, 2019-08-19

• Pten Loss in Olig2 Expressing Neural Progenitor Cells and Oligodendrocytes Leads to Interneuron Dysplasia and Leukodystrophy, 2014-06-09

• Microfluidic active loading of single cells enables analysis of complex clinical specimens, 2018-11-14

• The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location, 2022-12-05

• BRAFDuplications and MAPK Pathway Activation Are Frequent in Gliomas of the Optic Nerve Proper, 2012-08-02

• EGFRvariant heterogeneity in glioblastoma resolved through single-nucleus sequencing, 2014-06-03

• FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis, 2009-11-06

• Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma, 2018-09-13

• Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis, 2013-10-17

• The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma, 2019-01-25

• Somatic mutations associated with MRI-derived volumetric features in glioblastoma, 2015-09-04

• Prominin-1 (CD133) Defines Both Stem and Non-Stem Cell Populations in CNS Development and Gliomas, 2014-09-03

• Genomic sequencing of meningiomas identifies oncogenicSMOandAKT1mutations, 2013-01-20

• De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma, 2022-08-18

• Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas, 2014-08-12

• PDGFRAamplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma, 2013-03-18

• Temozolomide resistance in glioblastoma occurs by miRNA-9-targeted PTCH1, independent of sonic hedgehog level, 2015-02-06

• Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial, 2019-08-14

• Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate, 2016-10-10

• The central nervous system restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma, 2011-03-08

• Development of Stereotactic Mass Spectrometry for Brain Tumor Surgery, 2013-05-11

• A large peptidome dataset improves HLA class I epitope prediction across most of the human population, 2019-12-16

• FOXR2 is an epigenetically regulated pan-cancer oncogene that activates ETS transcriptional circuits, 2022-09-02

• A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2, 2017-03-28

• A PDGFRa-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine, 2018-08-06

• CHD4 regulates the DNA damage response and RAD51 expression in glioblastoma, 2019-03-14

• Early TP53 Alterations Engage Environmental Exposures to Promote Gastric Premalignancy in an Integrative Mouse Model, 2020-02-05

• Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma, 2014-12-31

• Combination inhibition of PI3K and mTORC1 yields durable remissions in orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases, 2016-06-06

• Tumor associated seizures in glioblastomas are influenced by survival gene expression in a region-specific manner: a gene expression imaging study, 2014-03-12

• Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq, 2018-04-20

• Somatic Activation of AKT3 Causes Hemispheric Developmental Brain Malformations, 2012-04-12

• Classifying Human Brain Tumors by Lipid Imaging with Mass Spectrometry, 2011-12-02

• MAPK activation andHRASmutation identified in pituitary spindle cell oncocytoma, 2016-05-09

• PPM1Dmutations are oncogenic drivers of de novo diffuse midline glioma formation, 2022-02-01

• Early EEG hyperexcitability is associated with decreased survival in newly diagnosed IDH-wildtype glioma, 2022-06-17

• MYB-QKI rearrangements in Angiocentric Glioma drive tumorigenicity through a tripartite mechanism, 2016-02-01

• Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Hedgehog-induced medulloblastoma, 2008-08-12

• Genomic characterization of brain metastases reveals branched evolution and potential therapeutic targets, 2015-09-26

• Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma, 2022-08-16

• Cancer-associated fibroblasts are the main contributors to epithelial-to-mesenchymal signatures in the tumor microenvironment, 2023-02-21

• Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities, 2013-09-29

• A novelGIT2-BRAFfusion in pilocytic astrocytoma, 2017-11-15

• Targeting glioblastoma using a novel peptide specific to a deglycosylated isoform of brevican, 2021-01-20

• Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas, 2020-09-29

• Rates and patterns of clonal oncogenic mutations in the normal human brain, 2021-08-13

• Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5, 2014-09-25

• Histone H3.3G34-mutant interneuron progenitors co-optPDGFRAfor gliomagenesis, 2020-11-30

• Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma, 2016-04-06

• Brainstem angiocentric gliomas with MYB-QKI rearrangements, 2017-08-12

• BRAF V600E Mutations Are Common in Pleomorphic Xanthoastrocytoma: Diagnostic and Therapeutic Implications, 2011-03-29

• K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas, 2022-12-05

• DNA Fragmentation Simulation Method (FSM) and Fragment Size Matching Improve aCGH Performance of FFPE Tissues, 2012-06-15

• Decrease in FOXJ1 expression and its ciliogenesis program in aggressive ependymoma and choroid plexus tumours, 2017-01-31

• Inhibitory CD161 Receptor Identified in Glioma-infiltrating T cells by Single Cell Analysis, 2021-02-15

• Recurrent somatic mutations inACVR1in pediatric midline high-grade astrocytoma, 2014-04-06

• Prospective, high-throughput molecular profiling of human gliomas, 2012-07-22

• Molecular and clinicopathologic features of gliomas harboringNTRKfusions, 2020-07-14

• Recurrent somatic alterations ofFGFR1andNTRK2in pilocytic astrocytoma, 2013-06-30

• Prospective Feasibility Trial for Genomics-Informed Treatment in Recurrent and Progressive Glioblastoma, 2017-10-26