Dr. Neill Graff-Radford, MD

• Neurology

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• University Of Iowa Hospitals And Clinics

  Fellowship Hospital

• Unconfirmed Foreign Training

  Residency Hospital

• University Iowa Hosps And Clinics

  Residency Hospital

• University Of Co School Of Med

  Residency Hospital

• Neurology Research Committee - Research Committee - Mayo Clinic Florida Committees, Member

• American Neurological Association, Member

• Research Financial Committee - Research Committee - Mayo Clinic Florida Committees, Member

• American Academy of Neurology, Member

• Behavioral Neurology Fellowship - Department of Neurology, Director

• Memory Disorders Research Society, Member

• Royal College of Medicine - London, Member

• Academy of Aphasia, Member

• Behavioral Neurology Society, Member

• American Board of Psychiatry and Neurology, Senior Examiner

• Alzheimers Disease Center, Executive Committee

• Science Committee - American Academy of Neurology, Member

• Profilin-1 mutations are rare in patients with amyotrophic lateral sclerosis and frontotemporal dementia, 2013-05-02

• Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain, 2016-04-26

• Chronic Traumatic Encephalopathy Pathology in a Neurodegenerative Disorders Brain Bank, 2015-10-30

• Reliable Change on the Boston Naming Test, 2012-01-23

• Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study, 2019-12-03

• Extensive transcriptomic study emphasizes importance of vesicular transport inC9orf72expansion carriers, 2019-10-08

• Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications, 2012-04-11

• Tracking white matter degeneration in asymptomatic and symptomaticMAPTmutation carriers, 2019-08-15

• Length of normal alleles ofC9ORF72GGGGCC repeat do not influence disease phenotype, 2012-07-26

• TYROBPgenetic variants in early-onset Alzheimer's disease, 2016-08-08

• Cancer and Vascular Comorbidity Effects on Dementia Risk and Neuropathology in the Oldest-old, 2022-11-19

• Evaluation of Memory Endophenotypes for Association withCLU,CR1andPICALMvariants in African-American and Caucasian Subjects, 2013-05-02

• Brain Expression Genome-Wide Association Study (eGWAS) Identifies Human Disease-Associated Variants, 2012-06-07

• Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer disease: a longitudinal study, 2018-02-01

• Whole-genome sequencing reveals important role forTBK1andOPTNmutations in frontotemporal lobar degeneration without motor neuron disease, 2015-05-06

• Biphasic cortical macro and microstructural changes in autosomal dominant Alzheimer disease, 2020-11-16

• Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort, 2023-04-12

• Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease, 2020-06-06

• Disproportionately enlarged subarachnoid-space hydrocephalus (DESH) in normal pressure hydrocephalus misinterpreted as atrophy: autopsy and radiological evidence, 2019-05-27

• Hippocampal sclerosis in the elderly: genetic and pathologic findings, some mimicking Alzheimer disease clinically, 2011-02-22

• An evaluation of the impact ofMAPT,SNCAandAPOEon the burden of Alzheimer and Lewy body pathology, 2012-01-30

• A truncating SOD1 mutation, p.Gly141X, is associated with clinical and pathologic heterogeneity, including frontotemporal lobar degeneration, 2015-04-28

• MAPThaplotype H1G is associated with increased risk of dementia with Lewy bodies, 2016-06-07

• Occupation attributes relate to location of atrophy in frontotemporal lobar degeneration, 2010-08-26

• Covariance-based vs. correlation-based functional connectivity dissociates healthy aging from Alzheimer disease, 2022-07-30

• Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease, 2023-08-07

• The limbic and neocortical contribution of a-synuclein, tau and ß-amyloid to disease duration in dementia with Lewy bodies, 2017-10-31

• Lewy body disease is a contributor to logopenic progressive aphasia phenotype, 2020-12-17

• Decreased body mass index in the preclinical stage of autosomal dominant Alzheimer's disease, 2017-04-27

• Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases, 2017-10-31

• ABI3andPLCG2missense variants as risk factors for neurodegenerative diseases in Caucasians and African Americans, 2018-10-11

• Evaluating pathogenic dementia variants in posterior cortical atrophy, 2015-10-08

• Apolipoprotein E regulates lipid metabolism and a-synuclein pathology in human iPSC-derived cerebral organoids, 2021-08-28

• Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases, 2016-02-01

• APOE4exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids, 2020-11-02

• AC6orf10/LOC101929163locus is associated with age of onset inC9orf72carriers, 2018-09-25

• MAPThaplotype diversity in multiple system atrophy, 2016-06-16

• Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer disease: a cross-sectional study, 2021-09-10

• An autoradiographic evaluation of AV-1451 Tau PET in dementia, 2016-06-13

• Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases, 2016-10-11

• Author Correction: APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids, 2021-05-05

• LRRK2variation and dementia with Lewy bodies, 2016-07-29

• Consensus classification of posterior cortical atrophy, 2017-03-02

• Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease, 2016-08-01

• Cerebrovascular disease, neurodegeneration, and clinical phenotype in dementia with Lewy bodies, 2021-05-14

• Internal Consistency and Test-Retest Stability of the Geriatric Depression Scale-Short Form in African American Older Adults, 2009-12-01

• TDP-43 represses cryptic exon inclusion in the FTD-ALS geneUNC13A, 2022-02-23

• TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease, 2013-06-21

• Differential clinicopathologic and Genetic features of late-onset amnestic dementias, 2014-06-05

• A candidate regulatory variant at theTREMgene cluster associates with decreased Alzheimer's disease risk, and increasedTREML1andTREM2brain gene expression, 2016-12-08

• Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer's disease brains, 2016-11-25

• Pathogenicity of exonic indels infused in sarcomain amyotrophic lateral sclerosis, 2010-11-12

• Clinical and volumetric changes with increasing functional impairment in familial frontotemporal lobar degeneration, 2020-01-06

• Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture, 2021-02-15

• Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease, 2020-08-01

• FTDP-17 WITH PICK BODY-LIKE INCLUSIONS ASSOCIATED WITH A NOVEL TAU MUTATION, p.E372G, 2016-10-05

• Sex and age interact to determine clinicopathologic differences in Alzheimer's disease, 2018-09-15

• Validation of the Neuropathologic Criteria of the Third Consortium for Dementia with Lewy Bodies for Prospectively Diagnosed Cases, 2009-07-15

• Selective Vulnerability of the Nucleus Basalis of Meynert Among Neuropathologic Subtypes of Alzheimer Disease Vulnerability of the Nucleus Basalis of Meynert Among Neuropathologic Subtypes of Alzheimer Disease, 2019-10-28

• Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics ofC9ORF72repeat expansion carriers, 2015-09-08

• Novel clinical associations with specificC9ORF72transcripts in patients with repeat expansions inC9ORF72, 2015-10-05

• Recognition memory and divergent cognitive profiles in prodromal genetic frontotemporal dementia, 2021-03-19

• Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer disease, 2019-03-04

• Common variants inMS4A4/MS4A6E, CD2uAP, CD33, andEPHA1are associated with late-onset Alzheimer's disease, 2011-04-03

• Cerebrospinal Fluid Dynamics and Discordant Amyloid Biomarkers, 2021-11-01

• Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium, 2022-01-31

• Diagnostic Validity of Age- And Education-Corrections for the Mini-Mental State Examination (MMSE) in African American Elders, 2011-12-08

• Association ofMAPThaplotypes with Alzheimer's disease risk andMAPTbrain gene expression levels, 2014-07-01

• Two novel loci,COBLandSLC10A2, for Alzheimer's disease in African Americans, 2016-10-20

• Mitochondrial genomic variation in dementia with Lewy bodies: association with disease risk and neuropathological measures, 2022-07-14

• Neuropathologically defined subtypes of Alzheimer's disease differ significantly from neurofibrillary tangle-predominant dementia, 2012-09-12

• Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal dementia and GRN mutations: a genome-wide association study, 2018-04-30

• Novel Mutations inTARDBP(TDP-43) in Patients with Familial Amyotrophic Lateral Sclerosis, 2008-09-19

• Ethnoracial differences in Alzheimer's disease from the FLorida Autopsied Multi-Ethnic (FLAME) cohort, 2019-02-18

• Novel mutation inMAPTexon 13 (p.N410H) causes corticobasal degeneration, 2013-11-19

• Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease, 2018-09-25

• TARDBPmutations in Parkinson's disease, 2012-12-08

• Correction to: A nonsynonymous mutation inPLCG2reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity, 2020-01-18

• APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia: Implications for therapeutic strategy, 2021-09-29

• Erratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain, 2016-05-23

• Longitudinal atrophy in prodromal dementia with Lewy bodies points to cholinergic degeneration, 2022-02-07

• Abnormal daytime sleepiness in dementia with Lewy bodies compared to Alzheimer's disease using the Multiple Sleep Latency Test, 2014-12-10

• Differential Item Functioning of the Boston Naming Test in Cognitively Normal African American and Caucasian Older Adults, 2009-07-02

• Late-Onset Alzheimer Risk Variants in Memory Decline, Incident Mild Cognitive Impairment and Alzheimer Disease, 2014-08-04

• Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: A retrospective study, 2011-07-27

• Transethnic genome-wide scan identifies novel Alzheimer disease loci, 2017-02-07

• Case Studies Illustrating Focal Alzheimer's, Fluent Aphasia, Late-Onset Memory Loss and Rapid Dementia, 2016-06-03

• Concurrent variably protease-sensitive prionopathy and amyotrophic lateral sclerosis, 2014-06-14

• Neuropathological differences by race from the National Alzheimer's Coordinating Center, 2016-04-16

• Genome-wide association interaction analysis for Alzheimer's disease, 2014-05-28

• Longitudinal Tau PET in Dementia with Lewy Bodies, 2022-03-08

• Rates of Brain Atrophy Across Disease Stages in Familial Frontotemporal Dementia Associated WithMAPT,GRN, andC9orf72Pathogenic Variants Rates of Brain Atrophy Across Disease Stages in Familial Frontotemporal Dementia, 2020-10-28

• TMEM106BprotectsC9ORF72expansion carriers against frontotemporal dementia, 2014-01-03

• Clinical and neuropathologic heterogeneity of c9FTD/ALS associated with hexanucleotide repeat expansion inC9ORF72, 2011-11-15

• FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration, 2010-05-20

• Transcriptomic analysis to identify genes associated with selective hippocampal vulnerability in Alzheimer's disease, 2021-04-19

• Genetic variants associated with susceptibility to psychosis in Late Onset Alzheimer Disease families, 2015-08-15

• TDP-43-regulated cryptic RNAs accumulate in Alzheimer's disease brains, 2023-08-21

• Genetic analysis implicatesAPOE, SNCAand suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies, 2014-06-27

• TDP-43 Frontotemporal Lobar Degeneration and Autoimmune Disease, 2013-03-30

• Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy, 2015-06-16

• Association ofABI3andPLCG2missense variants with disease risk and neuropathology in Lewy body disease and progressive supranuclear palsy, 2020-10-22

• Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing, 2019-02-28

• LRRTM3 Interacts with APP and BACE1 and Has Variants Associating with Late-Onset Alzheimer's Disease (LOAD), 2013-06-04

• A nonsynonymous mutation inPLCG2reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity, 2019-05-26

• Association of commonKIBRAvariants with episodic memory and AD risk, 2010-12-24

• C9ORF72hexanucleotide repeat expansions in clinical Alzheimer's disease, 2013-06-01

• Rare Variants inAPP,PSEN1andPSEN2Increase Risk for AD in Late-Onset Alzheimer's Disease Families, 2012-02-01

• Age-at-Onset in Late Onset Alzheimer Disease is Modified by Multiple Genetic Loci, 2015-01-13

• Evaluation of the Role ofSNCAVariants in Survival without Neurological Disease, 2012-08-13

• DNAJC13 p.Asn855Ser mutation screening in Parkinson's disease and pathologically confirmed Lewy body disease patients, 2015-05-20

• Daytime sleepiness in dementia with Lewy bodies is associated with neuronal depletion of the nucleus basalis of Meynert, 2018-02-03

• TREM2is associated with increased risk for Alzheimer's disease in African Americans, 2015-04-10

• The contribution of behavioral features to caregiver burden in FTLD-spectrum disorders, 2021-12-02

• Alzheimer's Disease: Scientific Breakthroughs and Translational Challenges, 2017-06-07

• Spt4 selectively regulates the expression ofC9orf72sense and antisense mutant transcripts associated with c9FTD/ALS, 2016-08-12

• CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer disease, 2022-03-28

• TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia, 2013-07-01

• Patterns of Brain Atrophy in Clinical Variants of Frontotemporal Lobar Degeneration, 2013-01-09

• Genome-wide analyses as part of the international FTLD-TDP whole genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD, 2019-02-09

• In-depth clinico-pathological examination of RNA foci in a large cohort ofC9ORF72expansion carriers, 2017-05-15

• Ataxin-2 as potential disease modifier inC9ORF72expansion carriers, 2014-05-02

• Latent trait modeling of tau neuropathology in progressive supranuclear palsy, 2021-02-26

• CCNFmutations in amyotrophic lateral sclerosis and frontotemporal dementia, 2016-04-15

• Common genetic variants in theCLDN2andPRSS1-PRSS2loci alter risk for alcohol-related and sporadic pancreatitis, 2012-11-11

• Evidence of cerebellar TDP-43 loss of function in FTLD-TDP, 2022-07-25

• APOEe2 is associated with increased tau pathology in primary tauopathy, 2018-10-22

• Genetic modifiers in carriers of repeat expansions in theC9ORF72gene, 2014-09-20

• Two rareAKAP9variants are associated with Alzheimer disease in African Americans, 2014-08-27

• Early Onset Alzheimer's Disease with Spastic Paraparesis, Dysarthria and Seizures and N135S Mutation inPSEN1, 2009-05-05

• The Longitudinal Early-onset Alzheimer's Disease Study (LEADS): Framework and methodology, 2021-05-21