Dr. Raif S Geha, MD

• Allergy & Immunology

• Pediatrics

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• American University Of Beirut

  Internship Hospital, 1999

• Boston Children's Hospital

  Fellowship Hospital, 1974

• Boston Children's Hospital

  Residency Hospital, 1971

• American University Of Beirut

  Medical School, 1969

• English

• Arabic

• French

• A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma, 2020-09-14

• Leukotriene B4driven neutrophil recruitment to the skin is essential for allergic skin inflammation, 2012-10-11

• A novel variant inSTAT2presenting with hemophagocytic lymphohistiocytosis, 2019-05-15

• Injury, dysbiosis and filaggrin deficiency drive skin inflammation via keratinocyte IL-1a release, 2018-09-19

• Transferrin receptor 1 is a cellular receptor for human heme-albumin, 2020-10-27

• Hyper IgM Syndrome: a Report from the USIDNET Registry, 2016-05-17

• Combined immunodeficiency with EBV positive B cell lymphoma and epidermodysplasia verruciformis due to a novel homozygous mutation inRASGRP1, 2017-08-16

• Hematopoietic Stem Cell Transplantation Outcomes for 11 Patients with Dedicator of Cytokinesis 8 (DOCK8) Deficiency, 2016-04-06

• Thymic stromal lymphopoietin and interleukin-33 promote skin inflammation and vaccinia virus replication in a mouse model of atopic dermatitis, 2016-01-29

• Severe disease and greater impairment of NF-?B activation in I?Ba point mutants versus truncation mutants in autosomal dominant anhidrotic ectodermal dysplasia with immune deficiency, 2017-06-17

• LPS-responsive beige-like anchor (LRBA) gene mutation in a family with inflammatory bowel disease and combined immunodeficiency, 2012-06-19

• A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency, 2015-12-07

• Regulatory T Cell Deficiency and Immune dysregulation, Polyendocrinopathy, Enteropathy, X-Linked-Like Disorder Due to Loss of Function Mutations inLRBA, 2014-11-17

• Multi-kingdom ecological drivers of microbiota assembly in preterm infants, 2021-02-24

• DOCK8 Deficiency Presenting as an IPEX-Like Disorder, 2017-10-23

• F-BAR domain only protein 1 (FCHO1) deficiency is a novel cause of combined immune deficiency in humans, 2019-02-26

• Flow cytometry biomarkers distinguish DOCK8 deficiency from severe atopic dermatitis, 2013-12-31

• CCL25/CCR9 Interactions Are Not Essential for Colitis Development but Are Required for Innate Immune Cell Protection from Chronic Experimental Murine Colitis, 2018-09-21

• ITK deficiency presenting as Autoimmune Lymphoproliferative Syndrome, 2020-07-04

• Efficacy and economics of targeted panel versus whole exome sequencing in 878 patients with suspected primary immunodeficiency, 2020-09-02

• A WIP peptide restores WASP levels and actin cytoskeleton reorganization in lymphocytes from patients withWASmutations that disrupt WIP binding, 2011-03-03

• Dysregulated actin dynamics in activated PI3Kd syndrome, 2019-11-21

• Successful engraftment of donor marrow following allogeneic hematopoietic cell transplantation in autosomal recessive Hyper IgE syndrome due to DOCK8 deficiency, 2010-09-07

• Food allergy: Insights into etiology, prevention and treatment provided by murine models, 2014-02-14

• ILC2 activation by keratinocyte-derived IL-25 drives IL-13 production at sites of allergic skin inflammation, 2020-06-01

• Plasmacytoid Dendritic Cell Depletion in DOCK8 Deficiency: Rescue of Severe Herpetic Infections with Interferon Alpha-2b Therapy, 2014-04-24

• Exaggerated T Follicular Helper Cell Responses in LRBA Deficiency Due to Failure of CTLA4-Mediated Regulation, 2017-06-07

• Presence of hypogammaglobulinemia and abnormal antibody responses in 1 GATA2 deficiency, 2014-04-14

• Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-?B essential modulator deficiency, 2008-10-11

• The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2-associated multisystem inflammatory syndrome in children, 2023-01-03

• Linker-Improved Chimeric Endolysin Selectively Kills Staphylococcus aureus In Vitro, on Reconstituted Human Epidermis, and in a Murine Model of Skin Infection, 2022-04-13

• DisseminatedMycobacterium malmoenseandSalmonellaInfections Associated with a Novel Variant inNFKBIA, 2017-04-17

• Hematopoietic Stem Cell Transplantation as Treatment for Patients with DOCK8 Deficiency, 2018-11-02

• Primary immunodeficiencies: 2009 update The International Union of Immunological Societies (IUIS) Primary Immunodeficiencies (PID) Expert Committee, 2009-11-24

• DOCK8 expression in Treg cells maintains their stability and limits contact hypersensitivity, 2020-11-07

• Human primary immunodeficiency caused by expression of a kinase-dead p110d mutant, 2018-10-16

• TRIF signaling is essential for TLR4-driven IgE class switching, 2014-02-14

• Combined immunodeficiency in a patient with deficiency of c-Rel, 2019-05-16

• Immune deficiency caused by impaired expression of nuclear factor-?B essential modifier (NEMO) because of a mutation in the 5' untranslated region of theNEMOgene, 2010-06-12

• A Homozygous mucosa-associated ly 1 mphoid tissue 1 (MALT1) mutation in a family with 2 combined immunodeficiency, 2013-05-31

• Successful hematopoietic stem cell transplantation in a 4-1BB deficient patient withEBV-induced lymphoproliferation, 2020-11-28

• Leucine-rich repeat containing 8A (LRRC8A)-dependent volume-regulated anion channel activity is dispensable for T-cell development and function, 2017-02-10

• Vaccinia immune globulin ameliorates eczema vaccinatum in a murine model of atopic dermatitis, 2011-12-22

• DOCK8 Regulates STAT3 Activation and Promotes Th17 Cell Differentiation, 2016-05-24

• The LRRC8A Mediated "Swell Activated” Chloride Conductance Is Dispensable for Vacuolar Homeostasis in Neutrophils, 2017-05-12

• Immunization with modified vaccinia virus Ankara prevents eczema vaccinatum in a murine model of atopic dermatitis, 2011-08-06

• A novel mutation inORAI1presenting with combined immunodeficiency and residual T cell function, 2015-06-09

• APRIL expression is upregulated in atopic dermatitis skin lesions and at sites of antigen driven allergic skin inflammation in mice, 2020-08-08

• A systematic analysis of recombination activity and genotype-phenotype correlation in human recombination-activating gene 1 deficiency, 2013-11-28

• Uses of Next-Generation Sequencing Technologies for the Diagnosis of Primary Immunodeficiencies, 2017-07-24

• IL-33 promotes food anaphylaxis in epicutaneously-sensitized mice by targeting mast cells, 2016-06-02

• Impaired T cell receptor activation in Interleukin-1 Receptor-associated Kinase-4-deficient patients, 2010-07-23

• Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus, 2015-01-30

• DOCK8 deficient patients have a breakdown in peripheral B cell tolerance and defective regulatory T cells, 2014-09-11

• TheCARD11-BCL10-MALT1 (CBM)signalosome complex: Stepping into the limelight of human primary immunodeficiency, 2014-07-17

• Immunodeficiency and Epstein Barr virus induced lymphoproliferation caused by 4-1BB deficiency, 2019-03-11

• Filaggrin deficient mice exhibit Th17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen, 2009-08-08

• Combined immunodeficiency with autoimmunity caused by a homozygous missense mutation in inhibitor of nuclear factor ?B kinase alpha (IKKa), 2021-09-17

• Recurrent viral infections associated with a homozygousCORO1Amutation that disrupts oligomerization and cytoskeletal association, 2015-10-21

• T cell mitochondrial dysfunction and lymphopenia in DOCK2-deficient patients, 2019-03-01

• WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis, 2018-05-03

• Comprehensive Genetic Results for Primary Immunodeficiency Disorders in a Highly Consanguineous Population, 2019-01-15

• TNFRSF13Bgenotypes control immune-mediated pathology by regulating the functions of innate B cells, 2021-09-08

• Functional analysis of TACI mutations associated with CVID, 2011-03-21

• RORa-expressing T regulatory cells restrain allergic skin inflammation, 2018-03-02

• Flow cytometry diagnosis of dedicator of cytokinesis 8 (DOCK8) deficiency, 2014-04-01

• The microbiota is important for IL-17A expression and neutrophil infiltration in lesional skin ofFlgft/ftmice, 2014-12-12

• Mechanical skin injury promotes food anaphylaxis by driving intestinal mast cell expansion., 2019-04-23

• Genotype and functional correlates of disease phenotype in deficiency of adenosine deaminase 2 (DADA2), 2020-01-13

• The C104R mutant impairs the function of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) through haploinsufficiency, 2011-06-17

• ILC2 activation by keratinocyte-derived IL-25 drives IL-13 production at sites of allergic skin inflammation, 2020-03-14

• A novel homozygous mutation inRecombination Activating Gene 2in two relatives with different clinical phenotypes: Omenn syndrome and Hyper-IgM syndrome, 2012-07-25

• Defective actin accumulation impairs human natural killer cell function in DOCK8 deficiency, 2013-02-04

• Immunologic reconstitution following hematopoietic stem cell transplantation despite lymph node paucity in NIK deficiency, 2018-11-14

• Immune dysregulation caused by homozygous mutations inCBLB, 2022-10-17

• Staphylococcus aureusexploits epidermal barrier defects in atopic dermatitis to trigger cytokine expression, 2016-07-02

• A novel truncating mutation in MYD88 in a patient with BCG adenitis, neutropenia and delayed umbilical cord separation, 2019-07-10

• JAK3 deficiency caused by a homozygous synonymous exonic mutation that creates a dominant splice site, 2016-12-10

• Filaggrin-dependent secretion of sphingomyelinase protects against staphylococcal a-toxin-induced keratinocyte death, 2012-12-11

• C3a receptor promotes viral containment in mice inoculated with vaccinia virus at sites of allergic skin inflammation, 2013-05-16

• Broad spectrum of autoantibodies in Wiskott-Aldrich Syndrome (WAS) and X-linked Thrombocytopenia (XLT), 2015-09-26

• Outcomes and treatment strategies for autoimmunity and hyperinflammation in patients with RAG deficiency., 2019-03-12

• Heterozygosity for TACI A144E causes haploinsufficiency and pneumococcal susceptibility in mice, 2016-09-05

• Consensus Middle East and North Africa Registry on Inborn Errors of Immunity, 2021-05-29

• Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food anaphylaxis, 2013-02-08

• A Phenotypic Approach for IUIS PID Classification and Diagnosis: Guidelines for Clinicians at the Bedside, 2013-05-09

• Basophil-derived IL-4 promotes cutaneous Staphylococcus aureus infection, 2021-11-08