Dr. Val Lowe, MD

• Radiology

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• Duke University Hospital

  Fellowship Hospital, 1993

• L D S Hospital

  Internship Hospital, 1989

• Orthotopic VX rabbit tongue cancer model with FDG-PET and histologic characterization, 2012-09-18

• DEPRESSIVE AND ANXIETY SYMPTOMS AND CORTICAL AMYLOID DEPOSITION AMONG COGNITIVELY NORMAL ELDERLY PERSONS: THE MAYO CLINIC STUDY OF AGING, 2017-12-04

• Association of Apolipoprotein E ?4, Educational Level, and Sex With Tau Deposition and Tau-Mediated Metabolic Dysfunction in Older Adults Association ofAPOE?4, Education, and Sex With Tau Pathology in Older Adults, 2019-10-23

• Brain Injury Biomarkers Are Not Dependent on ß-amyloid in Normal Elderly, 2013-02-19

• Association of functional performance with Alzheimer's disease biomarkers in non-demented individuals, 2018-11-21

• Multimodal neuroimaging relationships in progressive supranuclear palsy, 2019-07-02

• Longitudinal Tau PET in Dementia with Lewy Bodies, 2022-03-08

• Tau aggregation influences cognition and hippocampal atrophy in the absence of beta-amyloid: A clinico-imaging-pathological study of primary age related tauopathy (PART), 2017-02-03

• Association between CSF biomarkers of Alzheimer's disease and neuropsychiatric symptoms: Mayo Clinic Study of Aging, 2022-02-09

• Distinct regional anatomic and functional correlates of neurodegenerative apraxia of speech and aphasia: an MRI and FDG-PET study, 2013-03-28

• Functional connectivity to the premotor cortex maps onto longitudinal brain neurodegeneration in progressive apraxia of speech, 2022-09-02

• Association Between Plasma Biomarkers of Amyloid, Tau, and Neurodegeneration with Cerebral Microbleeds, 2022-09-02

• Comparison of [18F]Flutemetamol and [11C]Pittsburgh Compound-B in cognitively normal young, cognitively normal elderly, and Alzheimer's disease dementia individuals, 2017-08-14

• Varying degrees of temporoparietal hypometabolism on FDG-PET reveal amyloid-positive logopenic primary progressive aphasia is not a homogeneous clinical entity, 2018-03-21

• Cerebral Microbleeds: Relationship to Antithrombotic Medications, 2021-05-10

• Non-right handed primary progressive apraxia of speech, 2018-05-07

• RAB39Bgene mutations are not a common cause of Parkinson's disease or dementia with Lewy bodies, 2016-03-24

• Effect of Lifestyle Activities on AD Biomarkers and Cognition, 2012-06-18

• Neuroimaging Biomarkers and Impaired Olfaction in Cognitively Normal Individuals, 2017-06-09

• The many faces of globular glial tauopathy: a clinical and imaging study, 2022-11-01

• Identification of Site-specific Recurrence Following Primary Radiation Therapy for Prostate Cancer Using C-11 Choline Positron Emission Tomography/Computed Tomography: A Nomogram for Predicting Extrapelvic Disease, 2016-09-03

• The Value of Multimodal Imaging with123I-FP-CIT SPECT in Differential Diagnosis of Dementia with Lewy Bodies and Alzheimer's Disease Dementia, 2020-12-15

• Grey and white matter correlates of dysphagia in progressive supranuclear palsy, 2021-08-23

• Selective Worsening of Brain Injury Biomarker Abnormalities in Cognitively Normal Elderly with ß-amyloidosis, 2013-12-25

• 18F-fluorodeoxyglucose positron emission tomography, aging, and apolipoprotein E genotype in cognitively normal persons, 2014-03-11

• Regional ß-amyloid burden does not correlate with cognitive or language deficits in Alzheimer's disease presenting as aphasia, 2015-06-23

• Safety, pharmacokinetics, metabolism and radiation dosimetry of18F-tetrafluoroborate (18F-TFB) in healthy human subjects, 2017-10-27

• Medial temporal atrophy in posterior cortical atrophy and its relationship to the cingulate island sign, 2022-02-11

• Centiloid scaling for quantification of brain amyloid with [18F]flutemetamol using multiple processing methods, 2018-12-05

• Regional distribution, asymmetry and clinical correlates of tau uptake on [18F]AV-1451 PET in atypical Alzheimer's disease, 2018-09-01

• 18F-AV-1451 uptake differs between dementia with lewy bodies and posterior cortical atrophy Nedelska et al, 2019-01-07

• Longitudinal flortaucipir ([18F]AV-1451) PET uptake in Semantic Dementia, 2020-04-18

• Long-term associations between amyloid positron emission tomography, sex, apolipoprotein E and incident dementia and mortality among individuals without dementia: hazard ratios and absolute risk, 2022-02-02

• Impact of neck PET/CT positivity on survival outcomes - visual and quantitative assessment: Results from ACRIN 6685, 2022-12-07

• Traffic Jam at the Blood Brain Barrier Promotes Greater Accumulation of Alzheimer's Disease Amyloid-ß Proteins in the Cerebral Vasculature, 2013-03-05

• Dynamic Aphasia as a Variant of Frontotemporal Dementia, 2021-12-02

• Early Postmenopausal Transdermal 17ß-Estradiol Therapy and Amyloid-ß Deposition, 2016-05-07

• Optimizing PiB-PET SUVR Change-Over-Time Measurement by a large-scale analysis of Longitudinal Reliability, Plausibility, Separability, and Correlation with MMSE, 2016-08-27

• Optimum differentiation of FTLD from AD achieved with cross-sectional tau PET, 2022-08-29

• 18F-AV-1451 uptake differs between dementia with Lewy bodies and posterior cortical atrophy, 2019-01-07

• Mediterranean diet, its components and amyloid imaging biomarkers, 2018-06-28

• Predicting Progression to Mild Cognitive Impairment, 2019-01-07

• Effects of age on the glucose metabolic changes in mild cognitive impairment, 2010-03-18

• An MRI-based atlas for correlation of imaging and pathologic findings in Alzheimer's disease, 2016-03-28

• Prosodic and Phonetic Subtypes of Primary Progressive Apraxia of Speech, 2018-07-04

• Polygenic Scores of Alzheimer's Dementia Risk Genes Add Only Modestly toAPOEin Explaining Variation in Amyloid PET Burden, 2022-10-01

• Visualization of Neurofibrillary Tangle Maturity in Alzheimer's Disease: A Clinicopathologic Perspective for Biomarker Research, 2021-04-02

• BBBomics-Human Blood Brain Barrier Transcriptomics Hub, 2016-03-01

• Microbleeds in atypical presentations of Alzheimer's disease: a comparison to dementia of the Alzheimer's type, 2017-05-16

• Multimodality Imaging Characteristics of Dementia with Lewy Bodies, 2011-10-21

• [18F]AV-1451 clustering of entorhinal and cortical uptake in Alzheimer's disease, 2018-02-06

• Rates of transition between amyloid and neurodegeneration biomarker states and to dementia among non-demented individuals: a population-based cohort study, 2015-11-18

• Underlying pathology identified after 20 years of disease course in two cases of slowly progressive frontotemporal dementia syndromes, 2021-04-27

• [18F]AV-1451 tau-PET and primary progressive aphasia, 2018-03-13

• Age, Vascular Health, and Alzheimer's disease Biomarkers in an Elderly Sample, 2017-10-26

• Selecting software pipelines for change in flortaucipir SUVR: Balancing repeatability and group separation, 2021-06-09

• Pittsburgh compound B (PiB) PET imaging of meningioma and other intracranial tumors, 2017-11-08

• Considerations for Performing Level-2 Centiloid Transformations for Amyloid PET SUVR values, 2018-05-09

• A Carrier for Non-Covalent Delivery of Functional Beta-Galactosidase and Antibodies against Amyloid Plaques and IgM to the Brain, 2011-12-21

• [18F]AV-1451 tau-PET in progressive supranuclear palsy, 2016-10-27

• LRRK2variation and dementia with Lewy bodies, 2016-07-29

• MAPThaplotype H1G is associated with increased risk of dementia with Lewy bodies, 2016-06-07

• Cerebrovascular disease, neurodegeneration, and clinical phenotype in dementia with Lewy bodies, 2021-05-14

• Performance of plasma phosphorylated tau 181 and 217 in the community, 2022-05-26

• Longitudinal deterioration of white-matter integrity: heterogeneity in the ageing population, 2021-01-22

• Influence of amyloid and APOE on cognitive performance in a late middle-aged cohort, 2015-11-19

• The Role of FDG-PET and Staging Laparoscopy in the Management of Patients with Cancer of the Esophagus or Gastroesophageal Junction, 2010-05-18

• Clinical, FDG and amyloid PET imaging in posterior cortical atrophy, 2015-04-11

• Tumor-Derived Extracellular Vesicles Predict Clinical Outcomes in Oligometastatic Prostate Cancer and Suppress Antitumor Immunity, 2022-06-04

• Association of Cortical and Subcortical ß-Amyloid With Standardized Measures of Depressive and Anxiety Symptoms in Adults Without Dementia, 2020-10-22

• Phenotypic subtypes of progressive dysexecutive syndrome due to Alzheimer's disease: a series of clinical cases, 2022-02-25

• Evolution of Neurodegeneration Imaging Biomarkers from Clinically Normal to Dementia in the Alzheimer Disease Spectrum, 2016-06-16

• Posterior cortical atrophy phenotypic heterogeneity revealed by decoding18F-FDG-PET, 2021-08-19

• FDG PET and MRI in Logopenic Primary Progressive Aphasia versus Dementia of the Alzheimer's Type, 2013-04-23

• Metallopanstimulin as a marker for head and neck cancer, 2004-12-14

• Longitudinal Clinical, Neuropsychological, and Neuroimaging Characterization of a Kindred with a 12-Octapeptide Repeat Insertion inPRNP: The Next Generation, 2020-06-30

• Tau Uptake in Agrammatic Primary Progressive Aphasia with and without Apraxia of Speech, 2018-07-26

• Engineering Theranostic Nanovehicles Capable of Targeting Cerebrovascular Amyloid Deposits, 2014-04-13

• Uptake of AV-1451 in meningiomas, 2017-09-08

• Sex differences in grey matter networks in dementia with Lewy bodies, 2023-01-30

• CSF Phosphorylated Tau as an Indicator of Subsequent Tau Accumulation, 2022-05-26

• Cortical ß-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging, 2019-03-28

• Regional white matter hyperintensities in posterior cortical atrophy and logopenic progressive aphasia, 2022-07-28

• Brain Metabolic Changes with Longitudinal Transcutaneous Afferent Patterned Stimulation in Essential Tremor Subjects, 2020-12-16

• Distinct cytokine profiles in human brains resilient to Alzheimer's pathology, 2018-10-15

• 1H MR spectroscopy biomarkers of neuronal and synaptic function are associated with tau deposition in cognitively unimpaired older adults, 2022-01-05

• Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging-Alzheimer's Association Research Framework Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities, 2019-07-15

• Clinicopathological associations of hemispheric dominance in primary progressive apraxia of speech, 2023-03-15

• An autoradiographic evaluation of AV-1451 Tau PET in dementia, 2016-06-13

• AV-1451 Tau andß-Amyloid Positron Emission Tomography Imaging in Dementia With Lewy Bodies, 2016-12-19

• Tau-PET Correlates with Neuropathology Findings, 2020-01-04

• Dynamic aphasia with emerging agrammatism, anomia, and aberrant frontal behaviors in a case of atypical parkinsonism, 2022-07-20

• Defining imaging biomarker cut-points for brain aging and Alzheimer's disease, 2016-09-30

• Association of Bilateral Salpingo-Oophorectomy Before Menopause Onset With Medial Temporal Lobe Neurodegeneration Association of Bilateral Salpingo-Oophorectomy Before Menopause With Medial Temporal Lobe Neurodegeneration, 2018-10-15

• Antiphospholipid Syndrome Mimicking Posterior Cortical Atrophy and the "railroad track” sign on Brain Fluorodeoxyglucose-Positron Emission Tomography, 2023-03-17

• MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies, 2023-01-20

• APOE4 influences ß-amyloid burden in primary progressive aphasia and speech apraxia, 2014-06-28

• Association of Longitudinal ß-Amyloid Accumulation Determined by Positron Emission Tomography With Clinical and Cognitive Decline in Adults With Probable Lewy Body Dementia ß-Amyloid Accumulation and Decline in Adults With Probable Lewy Body Dementia, 2019-12-02

• Peptide Carrier-Mediated Non-Covalent Delivery of Unmodified Cisplatin, Methotrexate and Other Agents via Intravenous Route to the Brain, 2014-05-21

• The Evolution of Parkinsonism in Primary Progressive Apraxia of Speech: A 6-year longitudinal study, 2020-10-07

• Tau, Amyloid, and Cascading Network Failure across the Alzheimer's disease Spectrum, 2017-10-03

• Parkin-mediated mitophagy is negatively regulated by FOXO3A, which inhibits Plk3-mediated mitochondrial ROS generation in STZ diabetic stress-treated pancreatic ß cells, 2023-05-03

• Relationship ofAPOE, age at onset, amyloid and clinical phenotype in Alzheimer disease, 2021-08-25

• Antemortem amyloid imaging and ß-amyloid pathology in a case with dementia with Lewy Bodies, 2010-10-18

• NEMA NU 2-2007 performance measurements of the Siemens Inveon™preclinical small animal PET system, 2009-03-25

• FDG PET metabolic signatures distinguishing prodromal DLB and prodromal AD, 2021-07-04

• Neurobehavioral Characteristics of FDG-PET Defined Right Dominant Semantic Dementia: a longitudinal study, 2021-03-23

• Sex differences in brain atrophy in dementia with Lewy bodies, 2023-01-27

• Mitochondrial genomic variation in dementia with Lewy bodies: association with disease risk and neuropathological measures, 2022-07-14

• Imaging Biomarkers of Alzheimer's Disease in Multiple Sclerosis, 2020-02-08

• The role of age on tau PET uptake and grey matter atrophy in atypical Alzheimer disease, 2019-03-08

• Progressive dysexecutive syndrome due to Alzheimer's disease: a description of 55 cases and comparison to other phenotypes, 2020-05-27

• Longitudinal beta-amyloid PET in atypical Alzheimer's disease and frontotemporal lobar degeneration, 2020-03-04

• Neuroimaging Correlates with Neuropathologic Schemes in Neurodegenerative Disease, 2019-06-04

• Patterns of Recurrence Following Post-Prostatectomy Fossa Radiotherapy Identified by C-11 Choline PET/CT, 2016-11-17

• Tau Polygenic Risk Scoring: a Cost-Effective Aid for Prognostic Counseling in Alzheimer's Disease, 2022-04-12

• Longitudinal Flortaucipir ([18F]AV-1451) PET Imaging in Primary Progressive Apraxia of Speech, 2019-11-19

• Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau-PET and amyloid-PET, 2018-04-05

• FDG-PET/CTand Pathology in Newly Diagnosed Head and Neck Cancer: ACRIN 6685 Trial, FDG-PET/CT cN0, 2020-11-24

• White matter abnormalities are key components of cerebrovascular disease impacting cognitive decline, 2021-04-12

• White matter damage due to vascular, tau, and TDP-43 pathologies and its relevance to cognition, 2022-02-05

• Regional multimodal relationships between tau, hypometabolism, atrophy and fractional anisotropy in atypical Alzheimer's disease, 2018-12-13

• Statins and Brain Health: Alzheimer's and Cerebrovascular Disease Biomarkers in Older Adults, 2018-11-07

• Prospective trial evaluating the sensitivity and specificity of 3,4-dihydroxy-6-[18F]-fluoro-L-phenylalanine (18F-DOPA) PET and MRI in patients with recurrent gliomas, 2018-01-13

• Associations of quantitative susceptibility mapping with Alzheimer's disease clinical and imaging markers, 2020-10-06

• Imaging correlations of tau, amyloid, metabolism and atrophy in typical & atypical AD, 2018-03-30

• Lewy body disease is a contributor to logopenic progressive aphasia phenotype, 2020-12-17

• Elevated occipital ß-amyloid deposition is associated with widespread cognitive impairment in logopenic progressive aphasia, 2013-08-14

• Sleep quality and cortical amyloid-ß deposition in postmenopausal women of the Kronos Early Estrogen Prevention Study (KEEPS), 2021-03-03

• Diabetes and Elevated HbA1c levels are Associated with Brain Hypometabolism but not Amyloid Accumulation, 2014-03-20

• Atypical Alzheimer's disease phenotypes with normal or borderline PET biomarker profiles, 2022-08-24

• Multimodal Nanoprobes to target cerebrovascular amyloid in Alzheimer's disease brain, 2013-12-09

• Longitudinal tau-PET uptake and atrophy in atypical Alzheimer's disease, 2019-04-10

• Microbleeds in the logopenic variant of primary progressive aphasia, 2013-04-03

• Neurodegeneration of the visual word form area in a patient with word form alexia, 2021-05-24

• Perceived Misinterpretation Rates in Oncologic18F-FDG PET/CT Studies: A Survey of Referring Physicians, 2014-11-07

• Semimechanistic Population Pharmacokinetic Modeling to Investigate Amyloid Beta Trafficking and Accumulation at the BBB Endothelium, 2021-10-19

• Phase 1 Trial of Vismodegib and Erlotinib Combination in Metastatic Pancreatic Cancer, 2019-11-21

• Comparative assessment of regional tau distribution by Tau-PET and Post-mortem neuropathology in a representative set of Alzheimer's & frontotemporal lobar degeneration patients, 2023-05-11

• Relationships betweenß-amyloid and tau in an elderly population: An accelerated failure time model, 2021-07-29

• Sensitivity-specificity of tau and Aß PET in frontotemporal lobar degeneration, 2020-09-12

• Clinical and Neuroimaging Characteristics of Clinically Unclassifiable Primary Progressive Aphasia, 2019-08-13

• APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia: Implications for therapeutic strategy, 2021-09-29

• Joint associations of ß-amyloidosis and cortical thickness with cognition, 2018-02-02

• MRI outperforms [18F]AV-1451 PET as a longitudinal biomarker in progressive supranuclear palsy, 2018-11-23

• Characterizing White Matter Tract Degeneration in Syndromic Variants of Alzheimer's Disease: A Diffusion Tensor Imaging Study, 2023-03-19

• Natural COA water inhibits mitochondrial ROS-mediated apoptosis through Plk3 downregulation under STZ diabetic stress in pancreatic ß-cell lines, 2022-03-11

• A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech, 2021-06-08

• Global neuropathologic severity of Alzheimer's disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels, 2022-12-27

• Accelerated vs. unaccelerated serial MRI based TBM-SyN measurements for Clinical Trials in Alzheimer's disease, 2015-03-20

• Face recognition from research brain PET: An unexpected PET problem, 2022-06-03

• Posterior Cortical Atrophy: Primary Occipital Variant, 2022-03-30

• Clinical and neuroimaging biomarkers of amyloid-negative logopenic primary progressive aphasia, 2015-02-03

• Age-specific population frequencies of amyloidosis and neurodegeneration among cognitively normal people age 50-89 years: a cross-sectional study, 2014-09-04

• Tau-PET imaging with [18F]AV-1451 in Primary Progressive Apraxia of Speech, 2018-01-02

• Micro-computed tomography and nuclear magnetic resonance imaging for noninvasive, live-mouse cholangiography, 2013-04-15

• Deep learning-based brain age prediction in normal aging and dementia, 2022-05-09

• Multi-site study of the relationships betweenante mortem[11C]PIB-PET Centiloid values andpost mortemmeasures of Alzheimer's disease neuropathology., 2018-10-19

• Neuropsychological Profiles of Patients with Progressive Apraxia of Speech and Aphasia, 2021-07-22

• Phase II evaluation of Stereotactic Ablative Radiotherapy (SABR) and immunity in11C-Choline-PET/CT-identified oligometastatic castration-resistant prostate cancer, 2021-09-30

• Pittsburgh Compound B and AV-1451 Positron Emission Tomography Assessment of Molecular Pathologies of Alzheimer's disease in Progressive Supranuclear Palsy, 2017-12-13

• Ioflupane 123I (DAT scan) SPECT identifies dopamine receptor dysfunction early in the disease course in Progressive Apraxia of Speech, 2020-05-09

• Comparison of18F-FDG and PiB PET in Cognitive Impairment, 2009-05-14

• Relationship Between Risk Factors and Brain Reserve in Late Middle Age: Implications for Cognitive Aging, 2020-01-09

• Does amyloid deposition produce a specific atrophic signature in cognitively normal subjects?, 2013-01-24