Dr. Craig Hersh, MD

• Pulmonary Disease

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• Harvard Combined Training Prg

  Fellowship Hospital

• Hospital Of University Of Penn

  Residency Hospital

• Analysis of genetically driven alternative splicing identifies FBXO38 as a novel COPD susceptibility gene, 2019-07-03

• Chest CT Derived Low Fat-Free Mass Index and Mortality in COPD, 2017-12-14

• A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry, 2015-12-03

• Identifying a gene expression signature of frequent COPD exacerbations in peripheral blood using network methods, 2015-01-13

• Pharmacogenetics of chronic obstructive pulmonary disease: challenges and opportunities, 2010-02-24

• Multi-ethnic genome-wide and HLA association study of total serum IgE, 2021-09-15

• Increased chest CT derived bone and muscle measures capture markers of improved morbidity and mortality in COPD, 2022-11-15

• Multi-omics subtyping pipeline for chronic obstructive pulmonary disease, 2021-08-25

• Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD, 2014-06-25

• Lung tissue shows divergent gene expression between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis, 2022-04-21

• Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD, 2013-04-08

• Gene-based Segregation Method for Identifying Rare Variants in Family-based Sequencing Studies, 2017-02-13

• Epidemiology, radiology, and genetics of nicotine dependence in COPD, 2011-01-13

• Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis, 2014-02-07

• Risk factors for COPD exacerbations in inhaled medication users: the COPDGene study biannual longitudinal follow-up prospective cohort, 2016-02-10

• Cluster Analysis in the COPDGene Study Identifies Subtypes of Smokers with Distinct Patterns of Airway Disease and Emphysema, 2014-02-21

• Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study, 2018-10-29

• Peripheral blood microbial signatures in current and former smokers, 2021-10-06

• Clinical, physiologic, and radiographic factors contributing to development of hypoxemia in moderate to severe COPD: a cohort study, 2016-12-01

• Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease, 2018-01-15

• THE CLINICAL IMPACT OF NON-OBSTRUCTIVE CHRONIC BRONCHITIS IN CURRENT AND FORMER SMOKERS, 2013-11-15

• Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease, 2014-09-21

• Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus, 2014-10-24

• Comorbidities of COPD have a major impact on clinical outcomes, particularly in African Americans, 2015-02-05

• Genetic determinants in airways obstructive diseases: the case of asthma COPD overlap, 2022-06-30

• Genetic association analysis of COPD candidate genes with bronchodilator responsiveness, 2008-12-25

• Heme metabolism genes Downregulated in COPD Cachexia, 2020-05-01

• Variants inFAM13Aare associated with chronic obstructive pulmonary disease, 2010-02-21

• Screening for interaction effects in gene expression data, 2017-03-16

• RNA-sequencing across three matched tissues reveals shared and tissue-specific gene expression and pathway signatures of COPD, 2019-04-02

• Correction to: RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking, 2019-11-18

• Alternative poly-adenylation modulates a1-antitrypsin expression in chronic obstructive pulmonary disease, 2021-11-16

• Modifying roles of glutathione S-transferase polymorphisms on the association between cumulative lead exposure and cognitive function, 2013-08-16

• Clinical Predictors of Frequent Exacerbations in Subjects with Severe Chronic Obstructive Pulmonary Disease (COPD), 2010-12-10

• Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery, 2007-08-08

• Genomics and response to long-term oxygen therapy in chronic obstructive pulmonary disease, 2018-10-23

• Identifying miRNA-mRNA Networks Associated With COPD Phenotypes Identifying miRNA-mRNA COPD Networks, 2021-10-28

• RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking, 2017-10-06

• Beyond GWAS in COPD: Probing the landscape between gene-set associations, genome-wide associations and protein-protein interaction networks, 2014-08-27

• The clinical and genetic features of the COPD asthma overlap syndrome, 2014-05-29

• Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue, 2017-03-13

• Blood gene expression risk profiles and interstitial lung abnormalities: COPDGene and ECLIPSE cohort studies, 2022-06-17

• Novel Data Transformations for RNA-seq Differential Expression Analysis, 2019-03-18

• The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes, 2014-10-12

• A Genome-wide analysis of the response to inhaled beta2-agonists in Chronic Obstructive Pulmonary Disease, 2015-10-27

• DO "COPD SUBTYPES” REALLY EXIST? Assessment of COPD Heterogeneity and Clustering Reproducibility in 17,154 Individuals Across Ten Independent Cohorts, 2017-06-21

• The clinical features of the overlap between COPD and asthma, 2011-09-27

• Cigarette smoking-associated isoform switching and 3' UTR lengthening via alternative polyadenylation, 2021-11-08

• Gene expression analysis uncovers novel Hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells, 2013-03-01

• Clinical and Radiographic Correlates of Hypoxemia and Oxygen Therapy in the COPDGene Study, 2011-03-10

• A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci, 2009-03-20

• Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring, 2015-02-14

• Deep learning on graphs for multi-omics classification of COPD, 2023-04-21

• Network-based analysis reveals novel gene signatures in peripheral blood of patients with chronic obstructive pulmonary disease, 2017-04-24

• Distinct COPD subtypes in former smokers revealed by gene network perturbation analysis, 2023-01-25

• Genetics of Sputum Gene Expression in Chronic Obstructive Pulmonary Disease, 2011-09-16

• Blood eosinophil thresholds and exacerbations in chronic obstructive pulmonary disease, 2018-04-28

• Blood miRNAs Are Linked to Frequent Asthma Exacerbations in Childhood Asthma and Adult COPD, 2022-04-03

• DNAH5is associated with total lung capacity in chronic obstructive pulmonary disease, 2014-08-20

• Opportunities and Challenges in the Genetics of COPD 2010: An International COPD Genetics Conference Report, 2011-04-15

• Vitamin D deficiency is associated with respiratory symptoms and airway wall thickening in smokers with and without COPD: a prospective cohort study, 2020-05-04

• Do sputum or circulating blood samples reflect the pulmonary transcriptomic differences of COPD patients? A multi-tissue transcriptomic network META-analysis, 2019-01-08

• Blood RNA sequencing shows overlapping gene expression across COPD phenotype domains, 2021-06-24

• Meta-analysis of peripheral blood gene expression modules for COPD phenotypes, 2017-10-09

• Expression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: the Framingham Heart Study, 2023-08-10

• Hedgehog interacting protein-expressing lung fibroblasts suppress lymphocytic inflammation in mice, 2021-09-08

• Integrative genomics identifies new genes associated with severe COPD and emphysema, 2018-03-22

• It's more than low BMI: prevalence of cachexia and associated mortality in COPD, 2019-05-22

• Paradoxical Lung Function Response to Beta2-agonists: Radiologic Correlates and Clinical Implications, 2014-09-09

• Lung function trajectories in children with post-prematurity respiratory disease: identifying risk factors for abnormal growth, 2021-05-10

• Estimating drivers of cell state transitions using gene regulatory network models, 2017-12-13

• Diagnosing alpha-1 antitrypsin deficiency: the first step in precision medicine [version 1; referees: 3 approved], 2017-11-27

• Childhood pneumonia increases risk for chronic obstructive pulmonary disease: the COPDGene study, 2015-09-21

• Hepatitis C and HIV detection by blood RNA-sequencing in cohort of smokers, 2023-01-24

• Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD, 2016-08-17

• Significance of Medication History at the Time of Entry into the COPDGene Study: Relationship with Exacerbation and CT Metrics, 2015-09-11

• Genetic Associations and Architecture of Asthma-COPD Overlap, 2022-01-31

• PHENOTYPIC AND GENETIC HETEROGENEITY AMONG SUBJECTS WITH MILD AIRFLOW OBSTRUCTION IN COPDGENE, 2014-08-11

• An interferon inducible signature of airway disease from blood gene expression profiling, 2022-05-19

• Identifying chronic obstructive pulmonary disease from integrative omics and clustering in lung tissue, 2023-04-11

• CFTRvariants are associated with chronic bronchitis in smokers, 2022-08-10