Dr. Howard Weiner, MD

• Neurology

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• University Of Colorado At Denver

  Medical School, 1969

• Platelets Recognize Brain-Specific Glycolipid Structures, Respond to Neurovascular Damage and Promote Neuroinflammation, 2013-03-26

• Correlating serum microRNAs and clinical parameters in Amyotrophic lateral sclerosis, 2018-03-25

• Control of the gut microbiome by fecal microRNA, 2016-03-09

• Activated Human CD4+CD45RO+ Memory T-Cells Indirectly Inhibit NLRP3 Inflammasome Activation through Downregulation of P2X7R Signalling, 2012-06-29

• Platelets Play Differential Role During the Initiation and Progression of Autoimmune Neuroinflammation, 2015-08-20

• Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE, 2009-08-16

• Nasal administration of anti-CD3 mAb (Foralumab) downregulatesNKG7and increasesTGFB1andGIMAP7expression in T cells in subjects with COVID-19, 2023-03-07

• Alterations of the human gut microbiome in multiple sclerosis, 2016-06-28

• Systematic evaluation of RNA quality, microarray data reliability and pathway analysis in fresh, fresh frozen and formalin-fixed paraffin-embedded tissue samples, 2018-04-20

• IL-6 inhibits upregulation of membrane-bound TGF-beta 1 on CD4+ T cells and blocking IL-6 enhances oral tolerance, 2016-12-30

• The Aryl hydrocarbon Receptor (AhR) interacts with c-Maf to promote the differentiation of IL-27-induced regulatory type 1 (TR1) cells, 2010-08-01

• Nasal administration of anti-CD3 monoclonal antibody modulates effector CD8+ T cell function and induces a regulatory response in T cells in human subjects, 2022-11-23

• GEMS Project: A Platform to Investigate Multiple Sclerosis Risk, 2015-12-09

• Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting, 2023-03-30

• Evaluation of an Online Platform for Multiple Sclerosis Research: Patient Description, Validation of Severity Scale, and Exploration of BMI Effects on Disease Course, 2013-03-20

• The Innate Immune System in Demyelinating Disease, 2012-05-03

• microRNA-92a promotes CNS autoimmunity by modulating the regulatory and inflammatory T cell balance, 2022-05-16

• Latent-period stool proteomic assay of multiple sclerosis model indicates protective capacity of host-expressed protease inhibitors, 2019-08-28

• Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course, 2022-09-15

• Dominant role of microglial and macrophage innate immune responses in human ischemic infarcts Zrzavyet al, 2017-12-28

• Murine CD4 T Cells Produce a New Form of TGF-ß as Measured by a Newly Developed TGF-ß Bioassay, 2011-04-11

• Early miR-320b and miR-25-3p miRNA levels correlate with multiple sclerosis severity at 10 years: a cohort study, 2023-06-01

• Comparison of dimethyl fumarate and interferon outcomes in an MS cohort, 2022-07-11

• Oral Tolerance: Therapeutic Implications for Autoimmune Diseases, 2006-01-01

• Identification of Cytolytic CD161-CD56+Regulatory CD8 T Cells in Human Peripheral Blood, 2013-03-19

• The Short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction, 2012-11-01

• AHR activation is protective against colitis driven by T cells in humanized mice, 2016-10-25

• Identification of a novel mechanism of action of fingolimod (FTY720) on human effector T cell function through TCF-1 upregulation, 2015-12-30

• Gut-tropic T Cells that Express Integrin a4ß7 and CCR9 are Required for Induction of Oral Immune Tolerance in Mice, 2011-09-16

• Proximal and distal effects of genetic susceptibility to multiple sclerosis on the T cell epigenome, 2021-12-06

• Meta-analysis of genome scans and replication identifyCD6, IRF8andTNFRSF1Aas new multiple sclerosis susceptibility loci, 2009-06-14

• Calorie restriction slows age-related microbiota changes in an Alzheimer's disease model in female mice, 2019-11-29

• ?d T cell-secreted XCL1 mediates anti-CD3-induced oral tolerance, 2019-10-02

• Clinical Trial-Ready Patient Cohorts for Multiple System Atrophy: Coupling Biospecimen and iPSC Banking to Longitudinal Deep-Phenotyping, 2022-10-03

• Identification and characterization of latency-associated peptide-expressing ?d T cells, 2015-12-08

• Mucosal administration of CD3-specific monoclonal antibody inhibits diabetes in NOD mice and in a preclinical mouse model transgenic for the CD3 epsilon chain, 2016-10-10

• Adaptive Autoimmunity and Foxp3-Based Immunoregulation in Zebrafish, 2010-03-05

• MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-a-PU.1 pathway, 2010-12-05

• Ancestral risk modification for multiple sclerosis susceptibility detected across the Major Histocompatibility Complex in a multi-ethnic population, 2022-12-22

• The Host Shapes the Gut Microbiota via Fecal microRNA, 2016-01-13

• PD-L1+and XCR1+dendritic cells are region-specific regulators of gut homeostasis, 2021-08-13

• Novel CD8+Treg suppress EAE by TGF-ß- and IFN-?-dependent mechanisms, 2010-01-08

• Exploration of machine learning techniques in predicting multiple sclerosis disease course, 2017-04-05

• Nasal Administration of Anti-CD3 Monoclonal Antibody (Foralumab) Reduces Lung Inflammation and Blood Inflammatory Biomarkers in Mild to Moderate COVID-19 Patients: A Pilot Study, 2021-08-12

• The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases, 2017-09-19

• Oral Administration of OKT3 Monoclonal Antibody to Human Subjects Induces a Dose-Dependent Immunologic Effect in T Cells and Dendritic Cells, 2009-09-16

• Nasal administration of anti-CD3 monoclonal antibody ameliorates disease in a mouse model of Alzheimer's disease, 2023-09-05

• Immunotherapy of cereberovascular amloidosis in a transgenic mouse model, 2011-03-02

• The sex-specific interaction of the microbiome in neurodegenerative diseases, 2019-08-13

• Modeling Disease Severity in Multiple Sclerosis Using Electronic Health Records, 2013-11-11

• Deficiency of Thrombonspondin-1 Reduces Th17 Differentiation and Attenuates Experimental Autoimmune Encephalomyelitis, 2009-02-01

• A probiotic modulates the microbiome and immunity in multiple sclerosis, 2018-06-08

• Ensemble learning predicts multiple sclerosis disease course in the SUMMIT study, 2020-10-16

• Defective Induction of IL-27-Mediated Immunoregulation by Myeloid DCs in Multiple Sclerosis, 2023-04-28

• Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39, 2019-04-08

• An RNA Profile Identifies Two Subsets of Multiple Sclerosis Patients Differing in Disease Activity, 2012-09-26

• The microbiota restrains neurodegenerative microglia in a model of amyotrophic lateral sclerosis, 2022-03-11

• Effect of Natalizumab Treatment on Circulating Plasmacytoid Dendritic Cells: A Cross-Sectional Observational Study in Patients with Multiple Sclerosis, 2014-07-30

• Brain MRI lesion load at 1.5T and 3T vs. clinical status in multiple sclerosis, 2010-11-10

• V?1 and V?4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males, 2023-07-18

• Transcriptional signature of human pro-inflammatory TH17 cells identifies reducedIL10gene expression in multiple sclerosis, 2017-11-17

• Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice, 2014-11-27

• Dissection of multiple sclerosis genetics identifies B and CD4+ T cells as driver cell subsets, 2022-06-07

• Brain MRI predicts worsening multiple sclerosis disability over 5 years in the SUMMIT study., 2020-01-29

• Magnetic Resonance Disease Severity Scale predicts clinical progression in multiple sclerosis, 2009-10-06

• History of fatigue in multiple sclerosis is associated with grey matter atrophy, 2019-10-14

• Gamma-delta T cells modulate the microbiota and fecal micro-RNAs to maintain mucosal tolerance, 2023-02-23

• Oral tolerance, 2012-03-01

• Quantifying neurologic disease using biosensor measurements in-clinic and in free-living settings in multiple sclerosis, 2019-12-11

• Author Correction: Ensemble learning predicts multiple sclerosis disease course in the SUMMIT study, 2020-11-20

• Validation of Two Kinetic Assays for the Quantification of Endotoxin in Human Serum, 2021-06-25

• 3T MRI relaxometry detects T2 prolongation in the cerebral normal-appearing white matter in multiple sclerosis, 2009-03-10

• Mining the microbiota to identify gut commensals modulating neuroinflammation in a mouse model of multiple sclerosis, 2022-10-17

• TGF-ß Induces Surface LAP Expression on Murine CD4 T Cells Independent of Foxp3 Induction, 2010-11-24

• IL-27 Imparts Immunoregulatory Function to Human NK Cell Subsets, 2011-10-19

• A clonal model for human CD8+regulatory T cells: Unrestricted contact-dependent killing of activated CD4+T cells, 2011-11-28

• Immunoregulatory and tissue-residency programs modulated by c-MAF in human TH17 cells, 2018-09-10

• Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3+regulatory T cells, 2010-08-01

• Aging correlates with reduction in regulatory-type cytokines and T cells in the gut mucosa, 2011-05-14

• A Putative Alzheimer's Disease Risk Allele inPCK1Influences Brain Atrophy in Multiple Sclerosis, 2010-11-30

• CD8+T cells in neurodegeneration: friend or foe?, 2022-09-02

• Oral administration of miR-30d from feces of MS patients suppresses MS-like symptoms in mice by expandingAkkermansia muciniphila, 2019-11-26

• In VivoInduction of Tr1 Cells via Mucosal Dendritic Cells and AHR Signaling, 2011-08-23

• Hsp65-producingLactococcus lactisprevents experimental autoimmune encephalomyelitis in mice by inducing CD4+LAP+ regulatory T cells, 2012-08-28

• Identification of a Unique TGF-ß Dependent Molecular and Functional Signature in Microglia, 2013-12-08

• ?d T cells control humoral immune response by inducing T follicular helper cell differentiation, 2018-08-08

• Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity, 2019-09-24

• Checkpoint Receptor TIGIT Expressed on Tim-1+B Cells Regulates Tissue Inflammation, 2020-07-14

• SUMMIT: Creating a Repository of Deeply Phenotyped Contemporary Multiple Sclerosis Cohorts, 2017-08-29

• The Gut Microbiome in Progressive Multiple Sclerosis, 2021-04-30

• Corrigendum: Nasal Administration of Anti-CD3 Monoclonal Antibody (Foralumab) Reduces Lung Inflammation and Blood Inflammatory Biomarkers in Mild to Moderate COVID-19 Patients: A Pilot Study, 2022-01-12

• Depletion of TGF-ß from fetal bovine serum, 2010-09-15

• Increased leptin and A-FABP levels in relapsing and progressive forms of MS, 2013-11-11

• Acute microglia ablation induces neurodegeneration in the somatosensory system, 2018-11-01

• New immunosuppressive approaches: Oral administration of CD3-specific antibody to treat autoimmunity, 2008-09-18

• miRNA 548a-3p as biomarker of NEDA-3 at 2 years in multiple sclerosis patients treated with fingolimod, 2023-05-30

• Interferon-beta Inhibits Toll-Like Receptor 9 Processing in Multiple Sclerosis, 2010-11-30

• Targeting latency-associated peptide promotes anti-tumor immunity, 2017-05-19

• Scara1deficiency impairs clearance of soluble Amyloid-ß by mononuclear phagocytes and accelerates Alzheimer's-like disease progression, 2013-06-07

• Brain MRI lesions and atrophy are associated with employment status in patients with multiple sclerosis, 2015-07-24

• B4GALT6 regulates astrocyte activation during CNS inflammation, 2014-09-14

• Magnetic Resonance Disease Severity Scale (MRDSS) for patients with multiple sclerosis: a longitudinal study, 2011-12-28