Dr. Lois E Smith, MD

• Ophthalmology

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• Massachusetts Eye And Ear Infirmary

  Residency Hospital, 1989

• Boston Children's Hospital

  Fellowship Hospital, 1989

• Boston Children's Hospital|childrens Hospital

  Fellowship Hospital, 1989

• Beth Israel Deaconess Medical Center

  Internship Hospital, 1979

• Beth Israel Deaconess Medical Center|beth Israel Hosp-harvard

  Internship Hospital, 1979

• Boston University Chobanian & Avedisian School Of Medicine

  Medical School, 1978

• University Of British Columbia

  Undergraduate School, 1968

• Consensus guidelines for the use and interpretation of angiogenesis assays, 2018-06-19

• IGF1, serum glucose, and retinopathy of prematurity in extremely preterm infants, 2020-10-02

• PPARa is essential for retinal lipid metabolism and neuronal survival, 2017-11-28

• Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis, 2022-10-05

• Omega-3/Omega-6 Long-Chain Fatty Acid Imbalance in Phase I Retinopathy of Prematurity, 2022-03-23

• Neurodevelopmental disorders and somatic diagnoses in a national cohort of children born before 24 weeks of gestation, 2022-03-22

• Retinal Expression of Wnt-Pathway Mediated Genes in Low-Density Lipoprotein Receptor-Related Protein 5 (Lrp5) Knockout Mice, 2012-01-17

• Increased postnatal concentrations of pro-inflammatory cytokines are associated with reduced IGF-I levels and retinopathy of prematurity, 2017-11-27

• Retinopathy of prematurity: Metabolic risk factors, 2022-11-24

• Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche, 2020-08-05

• IGF-I in the clinics: Use in retinopathy of prematurity, 2016-09-28

• Validation of DIGIROP models and decision support tool for prediction of treatment for retinopathy of prematurity on a contemporary Swedish cohort, 2022-03-11

• Longitudinal infusion of a complex of insulin-like growth factor-I and IGF-binding protein-3 in five preterm infants: pharmacokinetics and short-term safety, 2012-10-24

• Individual Risk Prediction for Sight-Threatening Retinopathy of Prematurity Using Birth Characteristics Risk Prediction for Sight-Threatening Retinopathy of Prematurity Using Birth Characteristics, 2019-11-07

• rhIGF-1/rhIGFBP-3 in Preterm Infants: A Phase 2 Randomized Controlled Trial, 2018-11-22

• Effects of a lipid emulsion containing fish oil on polyunsaturated fatty acid profiles, growth and morbidities in extremely premature infants: A randomized controlled trial, 2017-05-03

• Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis, 2015-06-10

• Duration of anaemia during the first week of life is an independent risk factor for retinopathy of prematurity, 2018-01-11

• 5-Lipoxygenase Metabolite 4-HDHA Is a Mediator of the Antiangiogenic Effect of ?-3 Polyunsaturated Fatty Acids, 2011-02-09

• Aggressive posterior retinopathy of prematurity is associated with multiple infectious episodes and thrombocytopenia, 2016-09-16

• Cerebellar Exposure to Cell-Free Hemoglobin Following Preterm Intraventricular Hemorrhage: Causal in Cerebellar Damage?, 2017-06-10

• Retinal energy demands control vascular supply of the retina in development and disease: The role of neuronal lipid and glucose metabolism, 2017-11-22

• Calpain inhibitors reduce retinal hypoxia in ischemic retinopathy by improving neovascular architecture and functional perfusion, 2010-09-08

• Lutein facilitates physiological revascularization in a mouse model of retinopathy of prematurity, 2017-01-29

• Muller glial responses compensate for degenerating photoreceptors in retinitis pigmentosa, 2021-11-19

• IGF-1 as a Drug for Preterm Infants: A Step-Wise Clinical Development, 2018-01-23

• Leucocytosis is associated with retinopathy of prematurity in extremely preterm infants, 2019-04-12

• Analysis of candidate genes for macular telangiectasia type 2, 2010-12-14

• Development of a Retinopathy of Prematurity Activity Scale and Clinical Outcome Measures for Use in Clinical Trials, 2018-12-13

• Validation of the Retinopathy of Prematurity Activity Scale (ROP-ActS) using retrospective clinical data, 2020-06-26

• Iris metastasis as the initial presentation of metastatic esophageal cancer diagnosed by fine needle aspiration biopsy A case report, 2021-06-04

• FGF21 administration suppresses retinal and choroidal neovascularization in mice, 2017-02-14

• LRP5 Regulates Development of Lung Microvessels and Alveoli through the Angiopoietin-Tie2 Pathway, 2012-07-25

• National cohort of infants born before 24 gestational weeks showed increased survival rates but no improvement in neonatal morbidity, 2022-04-12

• Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation, 2022-03-22

• Optimization of an Image-Guided Laser-Induced Choroidal Neovascularization Model in Mice, 2015-07-10

• Review shows that donor milk does not promote the growth and development of preterm infants as well as maternal milk, 2019-01-25

• Sphingolipidomics of serum in extremely preterm infants: Association between low sphingosine-1-phosphate levels and severe retinopathy of prematurity, 2021-04-20

• Insulin-Like Growth Factor 1 in the Preterm Rabbit Pup: Characterization of Cerebrovascular Maturation following Administration of Recombinant Human Insulin-Like Growth Factor 1/Insulin-Like Growth Factor 1-Binding Protein 3, 2021-07-02

• Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis, 2009-10-08

• Current update on retinopathy of prematurity: screening and treatment, 2012-01-31

• Docosahexaenoic Acid and Arachidonic Acid Levels Are Associated with Early Systemic Inflammation in Extremely Preterm Infants, 2020-07-05

• Low Birth Weight Is a Risk Factor for Severe Retinopathy of Prematurity Depending on Gestational Age, 2014-10-15

• Moderate GSK-3ßinhibition improves neovascular architecture, reduces vascular leakage, and reduces retinal hypoxia in a model of ischemic retinopathy, 2010-09-01

• Sirtuin1 Over-Expression Does Not Impact Retinal Vascular and Neuronal Degeneration in a Mouse Model of Oxygen-Induced Retinopathy, 2014-01-08

• Dyslipidemia in retinal metabolic disorders, 2019-09-05

• IGF-1 and Anti-VEGF in ROP: Has the time come?, 2014-10-05

• Effect of Preterm Birth on Postnatal Apolipoprotein and Adipocytokine Profiles, 2015-04-29

• Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy, 2013-08-04

• Lipid metabolites in the pathogenesis and treatment of neovascular eye disease, 2011-03-18

• Nutrition, insulin-like growth factor-1 and retinopathy of prematurity, 2013-02-18

• Targeting Neurovascular Interaction in Retinal Disorders, 2020-02-22

• Review: Adiponectin in Retinopathy, 2016-05-04

• Development and validation of a new clinical decision support tool to optimize screening for retinopathy of prematurity, 2021-05-12

• The Biology of Retinopathy of Prematurity: How Knowledge of Pathogenesis Guides Treatment, 2013-05-21

• Altered cholesterol homeostasis in aged macrophages linked to neovascular macular degeneration, 2013-04-02

• Implementing higher oxygen saturation targets reduced the impact of poor weight gain as a predictor for retinopathy of prematurity, 2017-09-20

• Cellular senescence in pathologic retinal angiogenesis, 2021-04-13

• SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth, 2015-09-22

• Fatty acid oxidation and photoreceptor metabolic needs, 2021-02-06

• FGF21 via mitochondrial lipid oxidation promotes physiological vascularization in a mouse model of Phase I ROP, 2023-03-21

• WINROP Identifies Severe Retinopathy of Prematurity at an Early Stage in a Nation-Based Cohort of Extremely Preterm Infants, 2013-09-12

• Choroid Sprouting Assay: AnEx VivoModel of Microvascular Angiogenesis, 2013-07-26

• Vitreous metabolomics profiling of proliferative diabetic retinopathy, 2020-10-25

• Association of SomaticGNAQMutation With Capillary Malformations in a Case of Choroidal Hemangioma, 2019-01-01

• Wnt signaling mediates pathological vascular growth in proliferative retinopathy, 2011-10-03

• An Ex Vivo Choroid Sprouting Assay of Ocular Microvascular Angiogenesis, 2020-08-06

• Free fatty acid receptor 4 activation protects against choroidal neovascularization in mice, 2020-03-05

• Relationship of retinopathy of prematurity to brain volumes at term equivalent age and developmental outcome at 2 years corrected age in very preterm infants, 2018-04-12

• Altered Cholesterol Homeostasis in Aged Macrophages Linked to Neovascular Macular Degeneration, 2012-05-04

• Early Clinical Development of Cell Replacement Therapy: Considerations for the National Eye Institute Audacious Goals Initiative, 2017-03-29

• A Dosing Study of Bevacizumab for ROP: Late Recurrences and Additional Treatments, 2018-06-07

• Netrin-1 - DCC Signaling Systems and Age-Related Macular Degeneration, 2015-05-07

• Sphingosine 1-phosphate receptor signaling establishes AP-1 gradients to allow for retinal endothelial cell specialization, 2020-02-13

• Association of Retinopathy of Prematurity With Low Levels of Arachidonic Acid A Secondary Analysis of a Randomized Clinical Trial Association of Retinopathy of Prematurity With Low Levels of Arachidonic Acid, 2018-02-08

• Role of Insulinlike Growth Factor 1 in Fetal Development and in the Early Postnatal Life of Premature Infants, 2016-09-07

• Prognostic Value of Parenteral Nutrition Duration on Risk of Retinopathy of Prematurity Development and Validation of the Revised DIGIROP Clinical Decision Support Tool Prognostic Value of Parenteral Nutrition Duration on Risk of Retinopathy of Prematurity, 2023-06-29

• Retinal lipid and glucose metabolism dictates angiogenesis through lipid sensor Ffar1, 2016-03-14

• Association of Docosahexaenoic Acid and Arachidonic Acid Serum Levels With Retinopathy of Prematurity in Preterm Infants Association of DHA and AA Serum Levels With Retinopathy of Prematurity in Preterm Infants, 2021-10-14

• Serum concentrations of vascular endothelial growth factor in relation to retinopathy of prematurity, 2015-09-15

• Pathophysiology of diabetic retinopathy: Contribution and limitations of laboratory research, 2019-07-30

• Semaphorin 3F forms an anti-angiogenic barrier in outer retina, 2013-04-18

• Longitudinal Postnatal Weight Measurements for the Prediction of Retinopathy of Prematurity, 2015-04-08

• IGF-1 in retinopathy of prematurity, a CNS neurovascular disease, 2016-09-17

• PPAR? mediates a direct anti-angiogenic effect of ?3-PUFAs in proliferative retinopathy, 2010-07-15

• SIRT1 is essential for normal cognitive function and synaptic plasticity, 2010-07-21

• Comparing Alternative Ranibizumab Dosages for Safety and Efficacy in Retinopathy of Prematurity A Randomized Clinical Trial, 2018-03-01

• Erythropoietin serum levels, versus anaemia as risk factors for severe retinopathy of prematurity, 2018-09-18

• Long-Acting FGF21 Inhibits Retinal Vascular Leakage in In Vivo and In Vitro Models, 2020-02-11

• Cytochrome P450 oxidase 2J inhibition suppresses choroidal neovascularization in mice, 2022-07-19

• Use of Bayesian Networks to Probabilistically Model and Improve the Likelihood of Validation of Microarray Findings by RT-PCR, 2008-08-26

• Modification of serum fatty acids in preterm infants by parenteral lipids and enteral docosahexaenoic acid/arachidonic acid: A secondary analysis of the Mega Donna Mega trial, 2023-04-17

• Weight at first detection of retinopathy of prematurity predicts disease severity, 2014-06-24

• Effect of Enteral Lipid Supplement on Severe Retinopathy of Prematurity A Randomized Clinical Trial Effect of Enteral Lipids on Severe Retinopathy of Prematurity, 2021-02-01

• Decreased Platelet Counts and Serum Levels of VEGF-A, PDGF-BB, and BDNF in Extremely Preterm Infants Developing Severe ROP, 2021-02-19

• Randomized Control Trial of Postnatal rhIGF-1/rhIGFBP-3 Replacement in Preterm Infants:Post-hocAnalysis of Its Effect on Brain Injury, 2020-10-09

• Influence of Human Milk and Parenteral Lipid Emulsions on Serum Fatty Acid Profiles in Extremely Preterm Infants, 2018-04-21

• Association between low fatty acid levels and platelet count in infants with Retinopathy of Prematurity, 2020-06-29