Dr. Loren Walensky, MD

• Pediatric Hematology & Oncology

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• Boston Children's Hospital/dana-farber Cancer Institute, Pediatric Hematology/oncology

  Fellowship Hospital

• Boston Children's Hospital/boston Medical Center

  Residency Hospital

• Johns Hopkins School Of Medicine

  Medical School, 1997

• A PUMA mechanism unfolds, 2013-11-07

• Direct activation of BAX by BTSA1 overcomes apoptosis resistance in acute myeloid leukemia, 2017-10-09

• A Competitive Stapled Peptide Screen Identifies a Selective Small Molecule that Overcomes MCL-1-dependent Leukemia Cell Survival, 2012-09-21

• Inhibition of Pro-Apoptotic BAX by a Noncanonical Interaction Mechanism, 2015-02-12

• Hydrocarbon-stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor, 2020-05-27

• Biophysical Determinants for Cellular Uptake of Hydrocarbon-Stapled Peptide Helices, 2016-08-22

• MCL-1 is a master regulator of cancer dependency on fatty acid oxidation, 2022-10-04

• BH3-Triggered Structural Reorganization Drives the Activation of Pro-apoptotic BAX, 2010-11-12

• Targeted Disruption of the BCL9/ß-catenin Complex Inhibits Oncogenic Wnt Signaling, 2012-08-22

• Targeting a Helix-in-Groove Interaction Between E1 and E2 Blocks Ubiquitin Transfer, 2020-08-17

• Glucose-dependent partitioning of arginine to the urea cycle protects ß-cells from inflammation, 2020-05-11

• Phospho-BAD BH3 Mimicry Protects ß Cells and Restores Functional ß Cell Mass in Diabetes, 2015-01-29

• Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia, 2014-02-20

• Crystal Structures of Anti-Apoptotic BFL-1 and its Complex with a Covalent Stapled Peptide Inhibitor, 2017-12-21

• A redox switch regulates the structure and function of anti-apoptotic BFL-1, 2020-07-13

• Allosteric Inhibition of Anti-Apoptotic MCL-1, 2016-05-09

• Direct and selective small-molecule activation of proapoptotic BAX, 2012-05-27

• BAX Activation is Initiated at a Novel Interaction Site, 2008-10-23

• A Stapled p53 Helix Overcomes HDMX-Mediated Suppression of p53, 2010-11-16

• BAX Unleashed: The Biochemical Transformation of an Inactive Cytosolic Monomer into a Toxic Mitochondrial Pore, 2011-10-04

• Generation of Multiple Reporter Ions from a Single Isobaric Reagent Increases Multiplexing Capacity for Quantitative Proteomics, 2015-09-04

• Generation of Potent and Stable GLP-1 Analoguesvia‘Serine Ligation', 2022-03-23

• Cheating Death: New Molecules Block BAX, 2019-03-06

• Identification of a Structural Determinant for Selective Targeting of HDMX, 2020-04-30

• Photoreactive Stapled BH3 Peptides to Dissect the BCL-2 Family Interactome, 2010-12-22

• Multimodal Interaction with BCL-2 Family Proteins Underlies the Pro-Apoptotic Activity of PUMA BH3, 2013-07-25

• Homogeneous Oligomers of Pro-Apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization, 2020-06-12

• Stapled HIV-1 Peptides Recapitulate Antigenic Structures and Engage Broadly Neutralizing Antibodies, 2014-11-24

• Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency, 2022-06-27

• MDM2 and MDM4 are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors, 2019-02-12

• Mechanistic Validation of a Clinical Lead Stapled Peptide that Reactivates p53 by Dual HDM2 and HDMX Targeting, 2016-10-10

• Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD, 2018-03-01

• SWI/SNF mutant cancers depend upon catalytic and non-catalytic activity of EZH2, 2015-11-09

• Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering, 2020-05-14

• A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators, 2013-12-08

• Targeted Disruption of the EZH2/EED Complex Inhibits EZH2-dependent Cancer, 2013-08-25

• Design of Stapled Antimicrobial Peptides that Overcome Antibiotic Resistance and In Vivo Toxicity, 2019-08-19

• Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets, 2021-11-23

• Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX, 2020-03-10

• Brain and Testicular Tumors in Mice with Progenitor Cells Lacking BAX and BAK, 2012-09-17

• Cellular Uptake and Ultrastructural Localization Underlie the Proapoptotic Activity of a Hydrocarbon-stapled BIM BH3 Peptide, 2015-07-21

• Challenges in Targeting a Basic Helix-Loop-Helix Transcription Factor with Hydrocarbon-Stapled Peptides, 2016-10-04

• From Mitochondrial Biology to Magic Bullet: Navitoclax Disarms BCL-2 in Chronic Lymphocytic Leukemia, 2011-12-19

• Chemical Synthesis of Hydrocarbon-Stapled Peptides for Protein Interaction Research and Therapeutic Targeting, 2011-09-01

• Paclitaxel reduces axonal Bclw to initiate IP3R1-dependent axon degeneration, 2017-10-11

• The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core, 2021-08-13

• A non-apoptotic role for BAX and BAK in eicosanoid metabolism, 2015-04-06

• The MCL-1 BH3 Helix is an Exclusive MCL-1 inhibitor and Apoptosis Sensitizer, 2010-06-20

• Distinct BimBH3 (BimSAHB) Stapled Peptides for Structural and Cellular Studies, 2014-01-03

• Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer, 2018-09-25