Dr. Reisa Sperling, MD

• Neurology

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• Harvard Medical School

  Medical School, 1991

• Amyloid deposition detected with florbetapir F 18 (18F-AV-45) is related to lower episodic memory performance in clinically normal older individuals, 2012-08-09

• Nonlinear Distributional Mapping (NoDiM) for harmonization across amyloid-PET radiotracers, 2018-11-17

• Disruption of Functional Connectivity in Clinically Normal Older Adults Harboring Amyloid Burden, 2009-10-07

• Plasma IL-12/IFN-? axis predicts cognitive trajectories in cognitively unimpaired older adults, 2021-06-23

• Intrinsic interhemispheric hippocampal functional connectivity predicts individual differences in memory performance ability, 2009-12-30

• Subjective cognitive concerns, episodic memory and the APOE e4 allele, 2014-09-23

• Subjective Cognitive Decline in Older Adults: An Overview of Self-Report Measures Used Across 19 International Research Studies, 2015-09-24

• Loneliness, depression and cognitive function in older U.S. adults, 2016-05-09

• Development of a psychometrically equivalent short form of the Face-Name Associative Memory Exam for use along the early Alzheimer's disease trajectory, 2014-05-12

• Testing the Right Target and the Right Drug at the Right Stage, 2011-11-30

• Depressive symptoms and biomarkers of Alzheimer's disease in cognitively normal older adults, 2015-05-07

• Flexible modulation of network connectivity related to cognition in Alzheimer's disease, 2014-05-20

• Amyloid deposition is associated with impaired default network function in older persons without dementia, 2009-07-30

• Sex, Amyloid, andAPOEe4 and risk of cognitive decline in preclinical Alzheimer's disease: findings from three well-characterized cohorts, 2018-05-24

• Biomarker Validation of a Decline in Semantic Processing in Preclinical Alzheimer's Disease, 2015-11-23

• Memory self-awareness in the preclinical and prodromal stages of Alzheimer's disease, 2017-04-03

• Mild to Moderate Alzheimer Dementia with Insufficient Neuropathological Changes, 2014-04-08

• Neuropsychiatric symptoms and functional connectivity in mild cognitive impairment, 2015-06-25

• Associations between brainstem volume and Alzheimer's disease pathology in middle-aged individuals of the Framingham Heart Study, 2022-04-08

• APOE e4 does not modulate amyloid-ß associated neurodegeneration in preclinical Alzheimer's disease, 2012-09-13

• Early and late change on the preclinical Alzheimer's cognitive composite in clinically normal older individuals with elevated ß-amyloid, 2017-02-28

• Associations of Widowhood and ß-Amyloid With Cognitive Decline in Cognitively Unimpaired Older Adults Associations of Widowhood and ß-Amyloid With Cognitive Decline, 2020-02-26

• Neural basis for recognition confidence in younger and older adults, 2008-12-01

• Brain amyloid burden, sleep, and 24-hour rest/activity rhythms: screening findings from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration Studies, 2021-09-19

• Neuropsychiatric symptoms and global functional impairment along the Alzheimer's continuum, 2012-08-28

• Genetics of gene expression in the aging human brain reveal TDP-43 proteinopathy pathophysiology, 2020-06-10

• Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation toAPOEe4 allele status: a community-based cohort study, 2018-08-06

• Functional MRI Assessment of Task-Induced Deactivation of the Default Mode Network in Alzheimer's Disease and At-Risk Older Individuals, 2009-10-21

• Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals, 2020-11-27

• The encoding/retrieval flip: Interactions between memory performance and memory stage and relationship to intrinsic cortical networks, 2013-02-05

• Apathy is associated with lower inferior temporal cortical thickness in mild cognitive impairment and normal elderly, 2014-11-10

• Large-scale functional brain network abnormalities in Alzheimer's disease: Insights from functional neuroimaging, 2010-03-30

• Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease, 2018-11-09

• Relationships between default-mode network connectivity, medial temporal lobe structure, and age-related memory deficits, 2014-07-03

• Accelerated decline in white matter integrity in clinically normal individuals at risk for Alzheimer's disease, 2016-03-21

• KL*VS heterozygosity reduces brain amyloid in asymptomatic at- riskAPOE*4 carriers, 2021-01-23

• White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the Dominantly Inherited Alzheimer Network, 2016-04-27

• New ELISAs with high specificity for soluble oligomers of amyloid ß-protein detect natural Aß oligomers in human brain but not CSF, 2013-01-30

• Evidence of altered posteromedial cortical fMRI activity in subjects at risk for Alzheimer disease, 2009-06-22

• Face-name Associative Memory Performance is Related To Amyloid Burden in Normal Elderly, 2011-06-12

• Modulation of TREM2 byCD33: a protein QTL study integrates Alzheimer loci in human monocytes, 2015-09-28

• The Harvard Automated Phone Task: new performance-based activities of daily living tests for early Alzheimer's disease, 2015-06-05

• Vascular risk and ß-amyloid are synergistically associated with cortical tau, 2019-01-07

• Failure of repetition suppression and memory encoding in aging and Alzheimer's disease, 2011-01-27

• Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease, 2018-11-09

• Free and Cued Memory in relation to Biomarker-Defined Abnormalities in Clinically Normal Older Adults and Those at Risk for Alzheimer's Disease, 2015-05-19

• Clinical meaningfulness of subtle cognitive decline on longitudinal testing in preclinical AD, 2020-01-04

• Anosognosia for memory deficits in mild cognitive impairment: Insight into the neural mechanism using functional and molecular imaging, 2017-05-25

• Functional Connectivity in Autosomal Dominant and Late-Onset Alzheimer Disease, 2014-10-25

• Decline in cognitively complex everyday activities accelerates along the Alzheimer's disease continuum, 2020-10-29

• Neuroimaging Markers Associated with Maintenance of Optimal Memory Performance in Late-Life, 2017-05-01

• Executive function and instrumental activities of daily living in MCI and AD, 2010-05-05

• Amyloid-ß associated clinical decline occurs only in the presence of elevated p-tau, 2012-05-29

• Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia, 2011-06-21

• Association of anxiety with subcortical amyloidosis in cognitively normal older adults, 2018-08-16

• Tracking early decline in cognitive function in older individuals at risk for Alzheimer's disease dementia: the Alzheimer's Disease Cooperative Study Cognitive Function Instrument, 2015-04-01

• Inferior temporal tau is associated with accelerated prospective cortical thinning in clinically normal older adults, 2020-06-05

• Development and Validation of a Deep Learning Model for Earlier Detection of Cognitive Decline From Clinical Notes in Electronic Health Records Development and Validation of a Deep Learning Model for Earlier Detection of Cognitive Decline From Clinical Notes, 2021-11-18

• Visual short-term memory relates to tau and amyloid burdens in preclinical autosomal dominant Alzheimer's disease, 2020-08-21

• Selective Disruption of the Cerebral Neocortex in Alzheimer's Disease, 2010-09-23

• Differential Functional Response in the Posteromedial Cortices and Hippocampus to Stimulus Repetition During Successful Memory Encoding, 2012-02-17

• Amyloid-ß Associated Cortical Thinning in Clinically Normal Elderly, 2011-03-17

• APOE effects on regional tau in preclinical Alzheimer's disease, 2023-01-04

• Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease A Longitudinal Study Amyloid, Tau, and Cognition in Preclinical Alzheimer Disease, 2019-06-03

• Identifying sensitive measures of cognitive decline at different clinical stages of Alzheimer's disease, 2020-10-13

• Clinical Impact of Updated Diagnostic and Research Criteria for Alzheimer's Disease, 2014-05-02

• 18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal, 2018-05-09

• Activities of daily living measured by the Harvard Automated Phone Task track with cognitive decline over time in non-demented elderly, 2017-01-24

• Everyday Cognition scale items that best discriminate between and predict progression from clinically normal to mild cognitive impairment, 2014-09-02

• Menopause status moderates sex differences in tau burden: a Framingham PET Study, 2022-05-17

• Neural correlates of metamemory a comparison of feeling-of-knowing and retrospective confidence judgments, 2008-11-25

• Vascular disease and risk factors are associated with cognitive decline in the Alzheimer's disease spectrum, 2015-03-04

• Cognition, Reserve, and Amyloid Deposition in Normal Aging, 2011-02-10

• The neurophysiology and seizure outcomes of late onset unexplained epilepsy, 2020-09-19

• Monthly At-Home Computerized Cognitive Testing to Detect Diminished Practice Effects in Preclinical Alzheimer's Disease, 2022-01-13

• Dopamine transporter availability in clinically normal aging is associated with individual differences in white matter integrity, 2015-11-06

• Association of cortical microstructure with amyloid-ß and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults, 2021-09-29

• Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer disease, 2014-03-05

• Activities of daily living: where do they fit in the diagnosis of Alzheimer's disease?, 2012-10-01

• Large-Scale Functional Brain Network Abnormalities in Alzheimer's Disease: Insights from Functional Neuroimaging, 2009-10-21

• The Cortical Origin and Initial Spread of Medial Temporal Tauopathy in Alzheimer's Disease Assessed with Positron Emission Tomography, 2021-01-20

• PET staging of amyloidosis using striatum, 2018-05-21

• Associations of the Harvard Automated Phone Task and Alzheimer's Disease Pathology in Cognitively Normal Older Adults: Preliminary Findings, 2023-06-09

• ATREM1variant alters the accumulation of Alzheimer-related amyloid pathology, 2015-05-22

• Regional cortical thinning predicts worsening apathy and hallucinations across the Alzheimer's disease spectrum, 2013-07-24

• Association of Subjective Cognitive Decline with Markers of Brain Pathology in Preclinical Autosomal Dominant Alzheimer's Disease, 2019-12-24

• Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults, 2019-05-01

• Amyloid Related Imaging Abnormalities (ARIA) in Amyloid Modifying Therapeutic Trials: Recommendations from the Alzheimer's Association Research Roundtable Workgroup, 2013-06-03

• A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease, 2014-05-03

• Sex Mediates Relationships Between Regional Tau Pathology and Cognitive Decline, 2020-08-31

• Specific Subjective Memory Complaints in Older Persons May Indicate Poor Cognitive Function, 2011-09-15

• Resilience to autosomal dominant Alzheimer's disease in a Reelin-COLBOS heterozygous man, 2023-05-15

• Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease, 2009-02-11

• Regional tau pathology and loneliness in cognitively normal older adults, 2018-12-18

• Meaningful benefits: a framework to assess disease-modifying therapies in preclinical and early Alzheimer's disease, 2022-04-19

• Heterogeneity in clinically normal older participants classified as Suspected Non-Alzheimer's disease pathophysiology, 2016-10-01

• Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer's disease, 2019-01-31

• Resting-state functional connectivity and amyloid burden influence longitudinal cortical thinning in the default mode network in preclinical Alzheimer's disease, 2020-09-02

• Cortical atrophy in presymptomatic Alzheimer's disease presenilin 1 mutation carriers, 2012-11-07

• Subjective cognitive complaints and amyloid burden in cognitively normal older individuals, 2012-08-23

• The parahippocampal gyrus links the default-mode cortical network with the medial temporal lobe memory system, 2013-02-13

• Template based rotation: A method for functional connectivity analysis with a priori templates, 2014-08-21

• Physical Activity Is Positively Associated with Episodic Memory in Aging, 2016-01-10

• Harvard Aging Brain Study: dataset and accessibility, 2015-04-03

• Structural tract alterations predict down-stream tau accumulation in amyloid positive older individuals, 2018-02-05

• The AHEAD 3-45 Study: Design of a prevention trial for Alzheimer's disease, 2022-08-15

• Validation of the Face Name Associative Memory Exam in Cognitively Normal Older Individuals, 2012-03-09

• Maternal dementia age at onset in relation to amyloid burden in non-demented elderly offspring, 2015-12-28

• Subjective cognitive concerns and neuropsychiatric predictors of progression to the early clinical stages of Alzheimer's disease, 2014-02-26

• Apathy is associated with increased amyloid burden in mild cognitive impairment, 2014-03-12

• Measuring instrumental activities of daily living in non-demented elderly: a comparison of the new performance-based Harvard Automated Phone Task with other functional assessments, 2019-01-10

• Social Engagement and Amyloid-ß-Related Cognitive Decline in Cognitively Normal Older Adults, 2019-05-10

• Massachusetts alzheimer's disease research center: Progress and challenges, 2015-08-19

• Word retrieval across the biomarker-confirmed Alzheimer's disease syndromic spectrum, 2020-02-10

• Resistance to autosomal dominant Alzheimer's in anAPOE3-Christchurch homozygote: a case report, 2019-11-04

• Preclinical Alzheimer disease -the challenges ahead, 2012-11-27

• Age and amyloid-related alterations in default network habituation to stimulus repetition, 2011-02-18

• Biological and Cognitive Markers of Presenilin1 E280A Autosomal Dominant Alzheimer's Disease: A Comprehensive Review of the Colombian Kindred, 2019-12-04

• The impact of Aß and tau on prospective cognitive decline in older individuals, 2019-01-21

• Different Partial Volume Correction Methods Lead to Different Conclusions: an18F-FDG PET Study of Aging, 2016-02-23

• The Latin American Spanish version of the Face-Name Associative Memory Exam is sensitive to cognitive and pathological changes in preclinical autosomal dominant Alzheimer's disease, 2020-09-10

• Amyloid-beta burden predicts prospective decline in body mass index in clinically normal adults, 2020-03-07

• FDG metabolism associated with tau-amyloid interaction predicts memory decline, 2017-04-06

• Regional fluorodeoxyglucose metabolism and instrumental activities of daily living across the Alzheimer's disease spectrum, 2014-01-01

• SIST-M-IR activities of daily living items that best discriminate clinically normal elderly from those with mild cognitive impairment, 2014-07-31

• Longitudinal association of amyloid-ß and anxious-depressive symptoms in cognitively normal older adults, 2018-01-12

• Stress, resilience, and coping strategies in a sample of community-dwelling older adults during COVID-19, 2021-04-02

• Functional Connectivity in Multiple Cortical Networks Is Associated with Performance Across Cognitive Domains in Older Adults, 2015-10-01

• Striatal amyloid is associated with tauopathy and memory decline in familial Alzheimer's disease, 2019-02-04

• Intrinsic connectivity between the hippocampus and posteromedial cortex predicts memory performance in cognitively intact older individuals, 2010-02-24

• Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease, 2023-04-26

• Lower late-life body-mass index is associated with higher cortical amyloid burden in clinically normal elderly, 2016-06-18

• AnUNC5CAllele Predicts Cognitive Decline and Hippocampal Atrophy in Clinically Normal Older Adults, 2019-05-16

• A three-factor structure of cognitive functioning among carriers and non-carriers of autosomal-dominant Alzheimer's disease, 2019-12-28

• Cognitive Resilience in Clinical and Preclinical Alzheimer's Disease: The Association of Amyloid and Tau Burden on Cognitive Performance, 2017-01-13

• Functional Activities Questionnaire items that best discriminate and predict progression from clinically normal to mild cognitive impairment, 2015-05-08

• Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease, 2011-04-21

• The Feasibility of At-Home iPad Cognitive Testing For Use in Clinical Trials, 2015-11-15

• The A4 Study: Stopping AD before Symptoms Begin?, 2014-03-19

• Independent component analysis-based classification of Alzheimer's MRI data, 2013-06-21

• Synergism between fornix microstructure and beta-amyloid accelerates memory decline in clinically normal older adults, 2019-05-16

• Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data, 2017-04-25

• Lower novelty-related locus coeruleus function is associated with Aß-related cognitive decline in clinically healthy individuals, 2022-03-23

• Longitudinal Association of Depression Symptoms With Cognition and Cortical Amyloid Among Community-Dwelling Older Adults Association of Depression Symptoms With Cognition and Cortical Amyloid in Older Adults, 2019-08-09

• Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons, 2017-06-13

• Regional cortical thinning and cerebrospinal biomarkers predict worsening daily functioning across the Alzheimer disease spectrum, 2014-01-01

• Estimating total cerebral microinfarct burden from diffusion-weighted imaging, 2015-07-09

• In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer's disease pathology and cognitive decline, 2021-09-22

• Examining cognitive decline across black and white participants in the Harvard Aging Brain Study, 2020-07-09

• Ultra-high field imaging, plasma markers and autopsy data uncover a specific rostral locus coeruleus vulnerability to hyperphosphorylated tau, 2023-04-05

• Assessing Variant-Dependent Heterogeneity in ß-Amyloid Burden in Autosomal Dominant Alzheimer's Disease: a cross-sectional and longitudinal study, 2022-03-04

• Functional Alterations in Memory Networks in Early Alzheimer's Disease, 2011-01-24

• Depressive symptoms and tau accumulation in the inferior temporal lobe and entorhinal cortex in cognitively normal older adults: a pilot study, 2017-08-20

• Neurogenetic contributions to amyloid beta and tau spreading in the human cortex, 2018-10-29

• A Single Ascending Dose Study of Bapineuzumab in Patients With Alzheimer Disease, 2013-06-21

• What Happens with the Circuit in Alzheimer's Disease in Mice and Humans?, 2018-07-08

• Regional tau correlates of instrumental activities of daily living and apathy in mild cognitive impairment and Alzheimer's disease dementia, 2018-11-27

• Alzheimer's Biomarkers and Future Decline in Cognitive Normal Older Adults, 2018-01-13

• The Apathy Evaluation Scale: A Comparison of Subject, Informant, and Clinician Report in Cognitively Normal Elderly and Mild Cognitive Impairment, 2015-07-24

• The influence of demographic factors on subjective cognitive concerns and beta-amyloid, 2016-10-11

• Cortical microstructural changes predict tau accumulation and episodic memory decline in older adults harboring amyloid, 2023-08-01

• Location of pathogenic variants inPSEN1impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease, 2023-06-08

• BLOOD-BORNE ACTIVITY-DEPENDENT NEUROPROTECTIVE PROTEIN (ADNP) IS CORRELATED WITH PREMORBID INTELLIGENCE, CLINICAL STAGE AND ALZHEIMER'S DISEASE BIOMARKERS, 2015-11-30

• Cardiorespiratory fitness is differentially associated with cortical thickness in young and older adults, 2016-10-28

• Cognition, Reserve, and Amyloid Deposition in Normal Aging, 2009-10-27