Dr. Stuart Orkin, MD

• Pediatric Hematology & Oncology

• Pediatrics

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• Boston Children's Hospital

  Fellowship Hospital

• Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis, 2022-04-05

• Sox2 maintains self-renewal of tumor initiating cells in osteosarcomas, 2011-09-19

• Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment, 2018-09-25

• Calpain 2 Activation of P-TEFb Drives Megakaryocyte Morphogenesis and Is Disrupted by Leukemogenic GATA1 Mutation, 2013-12-23

• CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types, 2016-09-29

• Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing, 2011-10-13

• Hemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin, 2015-09-14

• Tandem Affinity Purification of Protein Complexes in Mouse Embryonic Stem Cells Using In Vivo Biotinylation, 2009-11-05

• Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation, 2020-01-20

• Chronic myelogenous leukemia initiating cells require Polycomb group protein EZH2, 2016-09-14

• Chromatin connections to pluripotency and cellular reprogramming, 2011-06-10

• Mathematical modeling of erythrocyte chimerism informs genetic intervention strategies for sickle cell disease, 2016-07-14

• Transcription control by the ENL YEATS domain in acute leukemia, 2017-03-01

• Recent advances in globin research using genome-wide association studies and gene editing, 2016-02-11

• High fat diet enhances stemness and tumorigenicity of intestinal progenitors, 2016-03-03

• Reactivation of a developmentally silenced embryonic globin gene, 2021-07-21

• Advances in the understanding of haemoglobin switching, 2010-03-01

• MicroRNA-21 Integrates Pathogenic Signaling to Control Pulmonary Hypertension: Results of a Network Bioinformatics Approach, 2012-02-27

• MicroRNA 21 promotes fibrosis of the kidney by silencing metabolic pathways, 2012-02-15

• A SinglecisElement Maintains Repression of the Key Developmental RegulatorGata2, 2010-09-09

• Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells, 2022-04-26

• MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets, 2012-03-16

• Serum-based culture conditions provoke gene expression variability in mouse embryonic stem cells as revealed by single cell analysis, 2016-01-21

• CD49b identifies functionally and epigenetically distinct subsets of lineage-biased hematopoietic stem cells, 2022-06-16

• Multiplexed capture of spatial configuration and temporal dynamics of locus-specific 3D chromatin by biotinylated dCas9, 2020-03-05

• Insights into GATA-1 Mediated Gene Activation versus Repression via Genome-wide Chromatin Occupancy Analysis, 2009-11-25

• An erythroid enhancer ofBCL11Asubject to genetic variation determines fetal hemoglobin level, 2013-10-11

• Functional footprinting of regulatory DNA, 2015-08-31

• Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis, 2019-06-28

• Prmt1-mediated translation regulation is a crucial vulnerability of cancer, 2017-06-27

• A Comparative Encyclopedia of DNA Elements in the Mouse Genome, 2014-11-20

• MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/interferon gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity, 2011-08-17

• The Polycomb-Dependent Epigenome Controls ß Cell Dysfunction, Dedifferentiation, and Diabetes, 2018-06-05

• CUT&RUNTools: a flexible pipeline for CUT&RUN processing and footprint analysis, 2019-09-09

• Mapping cellular hierarchy by single cell analysis of the cell surface repertoire, 2013-09-12

• TAF5L and TAF6L maintain self-renewal of embryonic stem cells via the MYC regulatory network, 2019-04-17

• Inactivation ofEedImpedesMLL-AF9Mediated Leukemogenesis ThroughCdkn2a-Dependent andCdkn2a-Independent Mechanisms in a Murine Model, 2015-06-26

• Genome-wide association studies of hematologic phenotypes: a window into human hematopoiesis, 2013-03-07

• Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture, 2021-10-29

• DNA Methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells, 2009-10-02

• Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation, 2010-11-07

• Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci, 2017-02-20

• Mouse regulatory DNA landscapes reveal global principles ofcis-regulatory evolution, 2014-11-21

• Extensive recovery of embryonic enhancer and gene memory stored in hypomethylated enhancer DNA, 2019-03-21

• Ezh2Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia, 2016-02-18

• Polycomb Repressive Complex 2 Regulates Normal Development of the Mouse Heart, 2011-12-08

• Functional interrogation of non-coding DNA through CRISPR genome editing, 2017-03-10

• Update on fetal hemoglobin gene regulation in hemoglobinopathies, 2011-04-19

• SWI/SNF mutant cancers depend upon catalytic and non-catalytic activity of EZH2, 2015-11-09

• Sustained PU.1 Levels Balance Cell-Cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem Cells, 2013-02-08

• Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-ß signalling, 2016-06-22

• Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation, 2013-06-18

• Zfp281 Functions as a Transcriptional Repressor for Pluripotency of Mouse Embryonic Stem Cells, 2011-09-13

• Epigenetic antagonism between Polycomb and SWI/SNF complexes during oncogenic transformation, 2010-10-19

• Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium, 2012-08-03

• Unleashing cell-intrinsic inflammation as a strategy to kill AML blasts, 2022-07-06

• A Cell-Permeant Nanobody-Based Degrader That Induces Fetal Hemoglobin, 2022-12-14

• Developmental and species-divergent globin switching are driven by BCL11A, 2009-08-05

• Jumonji modulates Polycomb activity and self-renewal versus differentiation of stem cells, 2009-12-24

• TIF1-GAMMA PLAYS AN ESSENTIAL ROLE IN MURINE HEMATOPOIESIS AND REGULATES TRANSCRIPTIONAL ELONGATION OF ERYTHROID GENES, 2012-11-16

• An engineered CRISPR/Cas9 mouse line for simultaneous readout of lineage histories and gene expression profiles in single cells, 2020-05-14

• Transcription factor competition at the ?-globin promoters controls hemoglobin switching, 2021-05-28

• Rb and hematopoiesis: stem cells to anemia, 2008-09-08

• ADAR1 is essential for maintenance of hematopoiesis and suppression of interferon signaling, 2008-12-07

• Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells, 2022-07-14

• Transcription factor competition at the ?-globin promoters controls hemoglobin switching, 2021-03-01

• A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia Transcriptional addiction in KMT2A-rearranged AML, 2022-03-01

• Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2, 2021-06-24

• Acquired tissue-specific promoter bivalency is a basis for PRC2 necessity in adult cells, 2016-05-19

• Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells, 2018-05-22

• Polycomb repressive complex 2 regulates hematopoietic stem cell maintenance and differentiation in a developmental stage-specific manner, 2013-11-14

• Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch, 2018-03-29

• The Public Repository of Xenografts (ProXe) enables discovery and randomized phase II-like trials in mice, 2016-04-11

• Regulation of haematopoietic multipotency by EZH1, 2018-01-17

• ReducedErgdosage impairs survival of hematopoietic stem and progenitor cells, 2017-04-24

• Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids, 2018-08-06

• Bcl11a-deficiency leads to hematopoietic stem cell defects with an aging-like phenotype, 2016-09-20

• Targeted Disruption of the EZH2/EED Complex Inhibits EZH2-dependent Cancer, 2013-08-25

• CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data, 2019-06-24

• Histone deacetylase inhibitors induce apoptosis in myeloid leukemia by suppressing autophagy, 2013-09-12

• A unified model of human hemoglobin switching through single-cell genome editing, 2021-08-17

• TIF1? controls erythroid cell fate by regulating transcription elongation, 2010-07-09

• Dietary suppression of MHC-II expression in intestinal epithelial cells enhances intestinal tumorigenesis, 2021-09-15

• Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments, 2018-04-12

• Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells, 2011-02-04

• Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin, 2016-01-15

• Combinatorial Assembly of Developmental Stage-Specific Enhancers Controls Gene Expression Programs during Human Erythropoiesis, 2012-10-04

• Polycomb deficiency drives a FOXP2-high aggressive state targetable by epigenetic inhibitors, 2023-01-20

• A human stem cell model of early Alzheimer's disease pathology in Down syndrome, 2012-02-15

• LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice, 2015-12-02

• The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability, 2015-04-14

• Analyzing CRISPR genome editing experiments with CRISPResso, 2016-07-12

• Characterizing heterogeneity in leukemic cells using single-cell gene expression analysis, 2014-12-03

• GATA4 mediates gene repression in the mature mouse small intestine through interactions with Friend of GATA (FOG) cofactors, 2008-07-26

• Generation of Genomic Deletions in Mammalian Cell Lines via CRISPR/Cas9, 2014-01-03

• Genome-wide CRISPR-Cas9 screen identifies leukemia-specific dependence on a pre-mRNA metabolic pathway regulated by DCPS, 2018-02-22

• Identifying quantitatively differential chromosomal compartmentalization changes and their biological significance from Hi-C data using DARIC, 2023-10-13

• The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells, 2016-12-19

• The ZebrafishmoonshineGene Encodes Transcriptional Intermediary Factor 1?, an Essential Regulator of Hematopoiesis, 2004-08-17

• A Myc rather than core pluripotency module accounts for the shared signatures of embryonic stem and cancer cells, 2010-10-15

• Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis, 2016-07-01

• Developmental control of Polycomb subunit composition by GATA factors mediates a switch to non-canonical functions, 2015-01-08

• Single-cell transcript profiles reveal multilineage priming in early progenitors derived from Lgr5+intestinal stem cells, 2016-08-11

• BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells, 2019-08-07

• Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis, 2016-01-11

• Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cells identity, 2013-12-19

• Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors, 2014-04-24

• PRC2 is required to maintain expression of the maternalGtl2-Rian-Mirglocus by preventingde novoDNA methylation in mouse embryonic stem cells, 2015-08-20

• Mapping the evolving landscape of super-enhancers during cell differentiation, 2021-09-15