Dr. Paul Yu, MD

• Cardiology

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• University Of Ca At San Francisco

  Internship Hospital

• Duke University School Of Medicine

  Medical School, 1999

• Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva, 2021-01-30

• A new link in the chain: unspliced XBP1 in Wnt signaling and vascular calcification, 2022-01-20

• NEDD9 targetsCOL3A1to promote endothelial fibrosis and pulmonary arterial hypertension, 2018-06-13

• Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva, 2021-04-22

• Protocol paper: a multi-center, double-blinded, randomized, 6-month, placebo-controlled study followed by 12-month open label extension to evaluate the safety and efficacy of Saracatinib in Fibrodysplasia Ossificans Progressiva (STOPFOP), 2022-06-01

• In Search of the Second Hit in PAH Editorial Comment on Abdul-Salam et al., Circulation Research 2018, 2019-01-04

• Applications of small molecule BMP inhibitors in physiology and disease, 2009-11-14

• BMP type I receptor inhibition reduces heterotopic ossification, 2008-11-30

• Novel Approaches to Imaging the Pulmonary Vasculature and Right Heart, 2022-04-28

• ACVR1R206Hreceptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A, 2015-09-02

• A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation, 2020-05-08

• Application ofin vitroDrug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP), 2019-04-24

• Inhibition of bone morphogenetic protein 6 receptors ameliorates Sjogren's syndrome in mice, 2020-02-19

• ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension, 2020-05-13

• Fibrodysplasia Ossificans Progressiva: What Have We Achieved and Where Are We Now? Follow-up to the 2015 Lorentz Workshop, 2021-11-10

• Hepcidin Regulation by BMP Signaling in Macrophages Is Lipopolysaccharide Dependent, 2012-09-13

• Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells, 2020-08-19

• A New Class of Small Molecule Inhibitor of BMP Signaling, 2013-04-30

• Dorsomorphin, a Selective Small Molecule Inhibitor of BMP Signaling, Promotes Cardiomyogenesis in Embryonic Stem Cells, 2008-08-06

• Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors, 2018-09-06

• Isolating pulmonary microvascular endothelial cellsex vivo: Implications for pulmonary arterial hypertension, and a caution on the use of commercial biomaterials, 2019-02-27

• Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension, 2022-05-12

• Coordinated modulation of circulating miR-21 in HIV, HIV-associated pulmonary arterial hypertension, and HIV/HCV co-infection, 2015-11-01

• Contributions of muscle-resident progenitor cells to homeostasis and disease, 2015-10-10

• Generation of an induced pluripotent stem cell line (TRNDi012-B) from Fibrodysplasia Ossificans Progressiva (FOP) patient carrying a heterozygous mutation c. 617G > A in theACVR1gene, 2021-06-07

• Development of an ALK2-biased BMP type I receptor kinase inhibitor, 2013-04-30

• ?Np63a Mediated Activation of Bone Morphogenetic Protein Signaling Governs Stem Cell Activity and Plasticity in Normal and Malignant Mammary Epithelial Cells, 2012-12-14

• Inhibition of Bone Morphogenetic Protein Signal Transduction Prevents the Medial Vascular Calcification Associated with Matrix Gla Protein Deficiency, 2015-01-20

• Diminished muscle integrity in patients with fibrodysplasia ossificans progressiva assessed with at-home electrical impedance myography, 2022-12-03

• Bone Morphogenetic Protein-2 Induces Non-Canonical Inflammatory and Oxidative Pathways in Human Retinal Endothelial Cells, 2021-01-29

• Augmentation of Smad-dependent BMP signaling in neural crest cells causes craniosynostosis in mice, 2013-01-20

• Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1, 2022-06-15

• Circulating NEDD9 is Increased in Pulmonary Arterial Hypertension A Multicenter, Retrospective Analysis, 2019-12-31

• Room with a View: Towards Molecular Imaging of Pulmonary Vascular Remodeling, 2018-07-25

• Wnt InhibitorsDkk1andSostAre Downstream Targets of BMP Signaling Through the Type IA Receptor (BMPRIA) in Osteoblasts, 2009-10-05

• Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification, 2016-11-23

• The obligatory role of Activin A in the formation of heterotopic bone in Fibrodysplasia Ossificans Progressiva, 2017-06-16

• A self-amplifying loop of YAP and SHH drives formation and expansion of heterotopic ossification, 2021-06-23

• Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification, 2019-12-10